Cytochrome c oxidase subunit 4 isoform 1 Recombinant Protein | COX41 recombinant protein

Recombinant Human Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Cat. Num. AAA9420129

• Gene Names: COX4I1; COX4; COXIV; COX4-1; COXIV-1; COX IV-1
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Cytochrome c oxidase subunit 4 isoform 1; Recombinant Human Cytochrome c oxidase subunit 4 isoform 1; mitochondrial; Cytochrome c oxidase polypeptide IVCytochrome c oxidase subunit IV isoform 1; COX IV-1; COX41 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 23-169aa

• Tag Info: His-SUMO-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for COX41 recombinant protein

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

NCBI and Uniprot Product Information

• NCBI GI #: 974005293
• NCBI GeneID: 1327
• NCBI Accession #: NP_001305715.1
• NCBI GenBank Nucleotide #: NM_001318786.1
• UniProt Accession #: P13073; Q6P666; B2R4J2; D3DUM7
• Molecular Weight: 33.2kD
• NCBI Official Full Name: cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 1
• NCBI Official Synonym Full Names: cytochrome c oxidase subunit 4I1
• NCBI Official Symbol: COX4I1
• NCBI Official Synonym Symbols: COX4; COXIV; COX4-1; COXIV-1; COX IV-1
• NCBI Protein Information: cytochrome c oxidase subunit 4 isoform 1, mitochondrial
• UniProt Protein Name: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
• Protein Family: Cytochrome c oxidase
• UniProt Gene Name: COX4I1
• UniProt Synonym Gene Names: COX4; COX IV-1

NCBI Description

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Uniprot Description

COX4I1: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Ubiquitous. Belongs to the cytochrome c oxidase IV family.

Protein type: EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex IV; mitochondrion; nucleus

Molecular Function: cytochrome-c oxidase activity; protein binding

Biological Process: generation of precursor metabolites and energy; mitochondrial electron transport, cytochrome c to oxygen