GRIK3 / GLUR7 Blocking Peptide | GRIK3 blocking peptide
GRIK3 / GLUR7 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]
Uniprot Description
GluR7: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.
Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component: axon; cell junction; dendrite; dendrite cytoplasm; integral to plasma membrane; perikaryon; plasma membrane; postsynaptic membrane; terminal button
Molecular Function: adenylate cyclase inhibiting metabotropic glutamate receptor activity; extracellular-glutamate-gated ion channel activity; G-protein-coupled receptor binding; glutamate receptor activity; ionotropic glutamate receptor activity; kainate selective glutamate receptor activity; ligand-gated ion channel activity
Biological Process: glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; metabotropic glutamate receptor signaling pathway; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; negative regulation of synaptic transmission, glutamatergic; regulation of membrane potential
Research Articles on GRIK3
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Product Notes
The GRIK3 grik3 (Catalog #AAA426324) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The GRIK3 / GLUR7 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-KIRQLPID SDDSRP. It is sometimes possible for the material contained within the vial of "GRIK3 / GLUR7, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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