NCBI Description
This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]
Uniprot Description
TAF1A: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 1q42
Cellular Component: intracellular membrane-bound organelle; microtubule cytoskeleton; nucleoplasm; nucleus; RNA polymerase I transcription factor complex
Molecular Function: protein binding
Biological Process: positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription from RNA polymerase I promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter
Product Notes
The TAF1A taf1a (Catalog #
AAA1271527) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgagtgatt tcagtgaaga attaaaaggg cctgtgacag atgatgaaga agtggaaaca tctgtgctca gtggtgcagg aatgcatttt ccttggcttc aaacatacgt agaaactgtg gccattggag ggaaaaggag gaaggatttt gctcagacaa caagtgcttg tttaagtttt atccaagaag ctctgctgaa gcaccaatgg cagcaagctg cagaatacat gtacagttat tttcagacct tggaagattc agatagctac aaaaggcagg ctgcacctga gattatttgg aagctcggaa gtgaaattct attttatcat cccaaaagca acatggagag tttcaatact tttgctaacc ggatgaaaaa tattggcgtc atgaattatt taaagatctc cttacaacat gcattatacc ttctgcatca tggaatgctt aaagatgcta agagaaatct gagtgaggca gagacatgga gacatggtga aaatacgtct tcccgggaaa tattaatcaa ccttattcag gcctataaag ggcttttaca gtattatacc tggtctgaaa agaagatgga attgtcaaag cttgataagg atgattatgc ttacaatgca gtagcccagg atgtgttcaa ccacagctgg aagacatctg caaatatttc tgcattgatt aaaattcctg gagtttggga cccttttgtg aagagttatg tagaaatgct ggaattctat ggggatcgag atggagccca agaggtactc accaattatg catatgatga aaagtttcca tcaaatccaa atgcccatat ctacttatac aactttctaa agagacagaa ggcaccaaga tcaaaattga taagtgtgct taagattttg tatcagattg taccatctca taaattgatg ttggaattcc atacattact tagaaaatca gaaaaagaag aacaccgtaa actggggttg gaggtattat ttggagtctt agattttgcc ggatgcacta agaatataac tgcttggaaa tacttggcaa aatatctgaa aaatatctta atgggaaacc accttgcgtg ggttcaagaa gagtggaact ccaggaaaaa ctggtggcca gggtttcatt tcagctactt ttgggcaaaa agtgattgga aggaagatac agctttggcc tgtgagaaag cttttgtggc tggtttactg ttaggaaaag gttgtagata tttccggtat attttaaagc aagatcacca aatcttaggg aagaaaatta agcggatgaa gagatctgtg aaaaaataca gtattgtaaa tccaagactc tga.
It is sometimes possible for the material contained within the vial of
"TAF1A, cDNA Clone" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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