KCNA5 cdna clone
KCNA5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]
Uniprot Description
Kv1.5: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation. Defects in KCNA5 are the cause of familial atrial fibrillation type 7 (ATFB7). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: caveola; Golgi apparatus; integral to plasma membrane; lipid raft; plasma membrane; voltage-gated potassium channel complex
Molecular Function: alpha-actinin binding; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; protein binding; protein kinase binding
Biological Process: membrane hyperpolarization; potassium ion transport; regulation of insulin secretion; regulation of membrane potential; regulation of potassium ion transport
Disease: Atrial Fibrillation, Familial, 7
Research Articles on KCNA5
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Product Notes
The KCNA5 kcna5 (Catalog #AAA1275665) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGAGATCG CCCTGGTGCC CCTGGAGAAC GGCGGTGCCA TGACCGTCAG AGGAGGCGAT GAGGCCCGGG CAGGCTGCGG CCAGGCCACA GGGGGAGAGC TCCAGTGTCC CCCGACGGCT GGGCTCAGCG ATGGGCCCAA GGAGCCGGCG CCAAAGGGGC GCGGCGCGCA GAGAGACGCG GACTCGGGAG TGCGGCCCTT GCCTCCGCTG CCGGACCCGG GAGTGCGGCC CTTGCCTCCG CTGCCAGAGG AGCTGCCACG GCCTCGACGG CCGCCTCCCG AGGACGAGGA GGAAGAAGGC GATCCCGGCC TGGGCACGGT GGAGGACCAG GCTCTGGGCA CGGCGTCCCT GCACCACCAG CGCGTCCACA TCAACATCTC CGGGCTGCGC TTTGAGACGC AGCTGGGCAC CCTGGCGCAG TTCCCCAACA CACTCCTGGG GGACCCCGCC AAGCGCCTGC GCTACTTCGA CCCCCTGAGG AACGAGTACT TCTTCGACCG CAACCGGCCC AGCTTCGACG GTATCCTCTA CTACTACCAG TCCGGGGGCC GCCTGCGGAG GCCGGTCAAC GTCTCCCTGG ACGTGTTCGC GGACGAGATA CGCTTCTACC AGCTGGGGGA CGAGGCCATG GAGCGCTTCC GCGAGGATGA GGGCTTCATT AAAGAAGAGG AGAAGCCCCT GCCCCGCAAC GAGTTCCAGC GCCAGGTGTG GCTTATCTTC GAGTATCCGG AGAGCTCTGG GTCCGCGCGG GCCATCGCCA TCGTCTCGGT CTTGGTTATC CTCATCTCCA TCATCACCTT CTGCTTGGAG ACCCTGCCTG AGTTCAGGGA TGAACGTGAG CTGCTCCGCC ACCCTCCGGC GCCCCACCAG CCTCCCGCGC CCGCCCCTGG GGCCAACGGC AGCGGGGTCA TGGCCCCGCC CTCTGGCCCT ACGGTGGCAC CGCTCCTGCC CAGGACCCTG GCCGACCCCT TCTTCATCGT GGAGACCACG TGCGTCATCT GGTTCACCTT CGAGCTGCTC GTGCGCTTCT TCGCCTGCCC CAGCAAGGCA GGGTTCTCCC GGAACATCAT GAACATCATC GATGTGGTGG CCATCTTCCC CTACTTCATC ACCCTGGGCA CCGAACTGGC AGAGCAGCAG CCAGGGGGCG GAGGAGGCGG CCAGAATGGG CAGCAGGCCA TGTCCCTGGC CATCCTCCGA GTCATCCGCC TGGTCCGGGT GTTCCGCATC TTCAAGCTCT CCCGCCACTC CAAGGGGCTG CAGATCCTGG GCAAGACCTT GCAGGCCTCC ATGAGGGAGC TGGGGCTGCT CATCTTCTTC CTCTTCATCG GGGTCATCCT CTTCTCCAGT GCCGTCTACT TCGCAGAGGC TGACAACCAG GGAACCCATT TCTCTAGCAT CCCTGACGCC TTCTGGTGGG CAGTGGTCAC CATGACCACT GTGGGCTACG GGGACATGAG GCCCATCACT GTTGGGGGCA AGATCGTGGG CTCGCTGTGT GCCATCGCCG GGGTCCTCAC CATTGCCCTG CCTGTGCCCG TCATCGTCTC CAACTTCAAC TACTTCTACC ACCGGGAAAC GGATCACGAG GAGCCGGCAG TCCTTAAGGA AGAGCAGGGC ACTCAGAGCC AGGGGCCGGG GCTGGACAGA GGAGTCCAGC GGAAGGTCAG CGGGAGCAGG GGATCCTTCT GCAAGGCTGG GGGGACCCTG GAGAATGCAG ACAGTGCCCG AAGGGGCAGC TGCCCCCTAG AGAAGTGTAA CGTCAAGGCC AAGAGCAACG TGGACTTGCG GAGGTCCCTT TATGCCCTCT GCCTGGACAC CAGCCGGGAA ACAGATTTGT GA. It is sometimes possible for the material contained within the vial of "KCNA5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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