CXXC4 cdna clone
CXXC4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Uniprot Description
CXXC4: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 4q24
Cellular Component: cytoplasm; cytoplasmic vesicle
Molecular Function: PDZ domain binding
Biological Process: negative regulation of Wnt receptor signaling pathway; zygotic determination of dorsal/ventral axis
Research Articles on CXXC4
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Product Notes
The CXXC4 cxxc4 (Catalog #AAA1271868) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCACCACC GAAACGACTC CCAGAGGCTG GGGAAAGCTG GCTGCCCGCC AGAGCCGTCG TTGCAAATGG CAAATACTAA TTTCCTCTCC ACCTTATCCC CTGAACACTG CAGACCTTTG GCGGGGGAAT GCATGAACAA GCTCAAATGC GGCGCTGCTG AAGCAGAGAT AATGAATCTC CCCGAGCGCG TGGGGACTTT TTCCGCTATC CCGGCTTTAG GGGGCATCTC ATTACCTCCA GGGGTCATCG TCATGACAGC CCTTCACTCC CCCGCAGCAG CCTCAGCAGC CGTCACAGAC AGTGCGTTTC AAATTGCCAA TCTGGCAGAC TGCCCGCAGA ATCATTCCTC CTCCTCCTCG TCCTCCTCAG GGGGAGCTGG CGGAGCCAAC CCAGCCAAGA AGAAGAGGAA AAGGTGTGGG GTCTGCGTGC CCTGCAAGAG GCTCATCAAC TGTGGCGTCT GCAGCAGTTG CAGGAACCGC AAAACGGGAC ACCAGATCTG CAAATTTAGA AAATGTGAAG AGCTAAAGAA AAAACCTGGC ACTTCACTAG AGAGAACACC TGTTCCCAGC GCTGAAGCAT TCCGATGGTT CTTTTAA. It is sometimes possible for the material contained within the vial of "CXXC4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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