ZFPM1 blocking peptide
ZFPM1 Blocking Peptide (C-term)
NCBI and Uniprot Product Information
Uniprot Description
FOG1: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2. Belongs to the FOG (Friend of GATA) family.
Protein type: Transcription regulation; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 16q24.2
Cellular Component: nucleoplasm; nucleus; transcription factor complex; transcriptional repressor complex
Molecular Function: protein binding; transcription factor binding
Biological Process: blood coagulation; cardiac muscle morphogensis; embryonic hemopoiesis; erythrocyte differentiation; heart development; megakaryocyte differentiation; negative regulation of fat cell differentiation; negative regulation of interleukin-4 biosynthetic process; negative regulation of protein binding; platelet formation; positive regulation of interferon-gamma biosynthetic process; T-helper cell lineage commitment
Research Articles on ZFPM1
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Product Notes
The ZFPM1 zfpm1 (Catalog #AAA9229879) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ZFPM1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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