SRp75 blocking peptide

SRp75 (D134) Peptide

Cat. Num. AAA3003007

• Gene Names: SRSF4; SFRS4; SRP75
• Applications: Blocking
• Purity: Synthetic peptide SRp75 (D134). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: SRp75; SRp75 (D134) Peptide; arginine/serine-rich 4; Pre mRNA splicing factor SRP75; Pre-mRNA-splicing factor SRP75; Serine/arginine-rich splicing factor 4; Splicing factor; arginine/serine rich 4; SRP001LB; SRP75; Srsf4; SRp75 blocking peptide

• Specificity: This peptide can be used with studies using MBS3003006 SRp75 (D134) pAb.
• Purity/Purification: Synthetic peptide SRp75 (D134). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 494

• Applicable Applications for SRp75 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for SRp75 blocking peptide

Serine/arginine-rich protein 75 (SRp75) is encoded by the SRSF4 gene. SRp75 belongs to the arginine/serine-rich factor family and likely plays a role in alternative mRNA splicing.The family of SR factors all contain one or more RNA recognition motifs (RRM) and an arginine/ serine (RS)-rich domain. They are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. The majority of SR proteins, including SC35 and SRp40, are confined to the nucleus, while SF2/ASF, SRp20, and 9G8 are continuously shuttled between the nucleus and the cytoplasm and contribute to mRNA transport. The activity of SR proteins in regulated splicing is antagonized by members of the hnRNP A/B family of proteins, which induce drastic shifts in the selection of splicing sites.

NCBI and Uniprot Product Information

• NCBI GI #: 21361282
• NCBI GeneID: 6429
• NCBI Accession #: NP_005617.2
• NCBI GenBank Nucleotide #: NP_005617.2
• UniProt Accession #: Q08170
• NCBI Official Full Name: serine/arginine-rich splicing factor 4
• NCBI Official Synonym Full Names: serine and arginine rich splicing factor 4
• NCBI Official Symbol: SRSF4
• NCBI Official Synonym Symbols: SFRS4; SRP75
• NCBI Protein Information: serine/arginine-rich splicing factor 4
• UniProt Protein Name: Serine/arginine-rich splicing factor 4
• UniProt Gene Name: SRSF4
• UniProt Synonym Gene Names: SFRS4; SRP75
• UniProt Entry Name: SRSF4_HUMAN

NCBI Description

This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]

Uniprot Description

SFRS4: Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. Belongs to the splicing factor SR family.

Protein type: Spliceosome; RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 1p35.3

Cellular Component: nucleoplasm; nuclear speck; nucleus

Molecular Function: nucleotide binding

Biological Process: RNA splicing, via transesterification reactions; nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase II promoter; mRNA export from nucleus; negative regulation of nuclear mRNA splicing, via spliceosome; RNA splicing; hemopoietic progenitor cell differentiation; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription