PRPF18 blocking peptide

PRPF18 Peptide

Cat. Num. AAA3006107

• Gene Names: PRPF18; PRP18; hPrp18
• Applications: Blocking
• Purity: Synthetic peptide PRPF18. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: PRPF18; PRPF18 Peptide; Pre-mRNA-splicing factor 18; PRP18 homolog; hPRP18; PRP18; HPRP18; PRPF18 blocking peptide

• Specificity: This peptide can be used with studies using MBS3006106 PRPF18 pAb.
• Purity/Purification: Synthetic peptide PRPF18. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 342

• Applicable Applications for PRPF18 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for PRPF18 blocking peptide

PRPF18 (pre-mRNA-splicing factor 18), also known as HPRP18, is a 342 amino acid protein that localizes to nuclear speckles and plays a role in the second step of pre-mRNA splicing. A member of the PRP18 family, PRPF18 contains seven WD repeats and exists as two alternatively spliced isoforms which are encoded by a gene located on human chromosome 10p13. Chromosome 10 contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10.

NCBI and Uniprot Product Information

• NCBI GI #: 4506123
• NCBI GeneID: 8559
• NCBI Accession #: NP_003666.1
• NCBI GenBank Nucleotide #: NP_003666.1
• UniProt Accession #: Q99633
• NCBI Official Full Name: pre-mRNA-splicing factor 18
• NCBI Official Synonym Full Names: pre-mRNA processing factor 18
• NCBI Official Symbol: PRPF18
• NCBI Official Synonym Symbols: PRP18; hPrp18
• NCBI Protein Information: pre-mRNA-splicing factor 18
• UniProt Protein Name: Pre-mRNA-splicing factor 18
• UniProt Gene Name: PRPF18
• UniProt Synonym Gene Names: HPRP18; hPRP18
• UniProt Entry Name: PRP18_HUMAN

NCBI Description

Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008]

Uniprot Description

PRPF18: Participates in the second step of pre-mRNA splicing. Belongs to the PRP18 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Spliceosome; RNA splicing

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: spliceosome; nuclear speck; nucleus

Molecular Function: potassium channel inhibitor activity

Biological Process: RNA splicing; mRNA processing