p-EF-2 blocking peptide

p-EF-2 (T56) Peptide

Cat. Num. AAA3004596

• Gene Names: EEF2; EF2; EF-2; EEF-2; SCA26
• Applications: Blocking
• Purity: Synthetic peptide p-EF-2 (T56). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: p-EF-2; p-EF-2 (T56) Peptide; EEF 2; Eef2; EF-2; EF2; Elongation factor 2; Eukaryotic translation elongation factor 2; Polypeptidyl tRNA translocase; p-EF-2 blocking peptide

• Specificity: This peptide can be used with studies using MBS3004595 p-EF-2 (T56) pAb.
• Purity/Purification: Synthetic peptide p-EF-2 (T56). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 858

• Applicable Applications for p-EF-2 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for p-EF-2 blocking peptide

Two elongation factors (EF) EF-Tu and EF-2 participate in the elongation phase during protein biosynthesis on the ribosome and their functional cycles depend on GTP binding and its hydrolysis. EF-Tu (also designated mitochondrial precursor p43) and EF-2 are multidomain GTPases with essential functions in translation, and they both bind to the same site on the ribosome where their low intrinsic GTPase activities are strongly stimulated. EF-Tu plays a central role in the fast and accurate delivery of aminoacyl-tRNAs to the translating ribosome. In addition, EF-Tu protects the aminoester bond against hydrolysis until a correct match between the codon on mRNA and the anticodon on tRNA can be achieved.

NCBI and Uniprot Product Information

• NCBI GI #: 4503483
• NCBI GeneID: 1938
• NCBI Accession #: NP_001952.1
• NCBI GenBank Nucleotide #: NP_001952.1
• UniProt Accession #: P13639
• NCBI Official Full Name: elongation factor 2
• NCBI Official Synonym Full Names: eukaryotic translation elongation factor 2
• NCBI Official Symbol: EEF2
• NCBI Official Synonym Symbols: EF2; EF-2; EEF-2; SCA26
• NCBI Protein Information: elongation factor 2
• UniProt Protein Name: Elongation factor 2
• UniProt Gene Name: EEF2
• UniProt Synonym Gene Names: EF2; EF-2
• UniProt Entry Name: EF2_HUMAN

NCBI Description

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]

Uniprot Description

EEF2: a member of the GTP-binding translation elongation factor family. An essential factor for protein synthesis. Promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by eEF2 kinase phosphorylation. eEF2 kinase is normally dependent on Ca2+ ions and calmodulin. eEF2 kinase can also be activated by PKA in response to elevated cAMP levels, which are generally increased in stress- or starvation-related conditions. A variety of treatments known to raise intracellular Ca2+ or cAMP levels have been shown to result in increased phosphorylation of eEF2, and thus to inhibit peptide-chain elongation.

Protein type: Translation elongation; Translation

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: polysome; membrane; cytoplasm; plasma membrane; nucleus; cytosol; ribonucleoprotein complex

Molecular Function: GTPase activity; protein binding; GTP binding; protein kinase binding; translation elongation factor activity

Biological Process: cellular protein metabolic process; translational elongation; positive regulation of translation; translation; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; pathogenesis; gene expression; hemopoietic progenitor cell differentiation; post-translational protein modification

Disease: Spinocerebellar Ataxia 26