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MORC2 blocking peptide

MORC2 Blocking Peptide (C-term)

Gene Names
MORC2; ZCW3; CMT2Z; ZCWCC1
Synonyms
MORC2; MORC2 Blocking Peptide (C-term); MORC family CW-type zinc finger protein 2; Zinc finger CW-type coiled-coil domain protein 1; KIAA0852; ZCWCC1; MORC2 blocking peptide
Ordering
Specificity
The synthetic peptide sequence is selected from aa 848-862 of HUMAN MORC2
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
1032
Cellular Location
Nucleus. Cytoplasm, cytosol. Note: Mainly located in the nucleus
Tissue Location
Highly expressed in smooth muscle, pancreas and testis
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for MORC2 blocking peptide
Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation. May act as a transcriptional repressor. Down-regulates CA9 expression.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
110,724 Da
NCBI Official Full Name
MORC family CW-type zinc finger protein 2
NCBI Official Synonym Full Names
MORC family CW-type zinc finger 2
NCBI Official Symbol
MORC2
NCBI Official Synonym Symbols
ZCW3; CMT2Z; ZCWCC1
NCBI Protein Information
MORC family CW-type zinc finger protein 2
UniProt Protein Name
MORC family CW-type zinc finger protein 2
UniProt Gene Name
MORC2
UniProt Synonym Gene Names
KIAA0852; ZCWCC1
UniProt Entry Name
MORC2_HUMAN

NCBI Description

This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

Uniprot Description

MORC2: a protein containing a Zinc finger CW-type coiled-coil domain and a HATPase_c domain. HATPase_c domains are found in several ATP-binding proteins including histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, and DNA mismatch repair proteins.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: cytoplasm; nucleus

Research Articles on MORC2

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Product Notes

The MORC2 morc2 (Catalog #AAA9229225) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MORC2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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