MINK1 blocking peptide

MINK1 Blocking Peptide

Cat. Num. AAA9619609

• Gene Names: MINK1; B55; ZC3; MINK; YSK2; hMINK; MAP4K6; hMINKbeta
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: MINK1; MINK1 Blocking Peptide; B55; GCK family kinase MiNK; hMINK; Map4k6; MAPK/ERK kinase kinase kinase 6; MEK (MAP/ERK) kinase kinase 6; MEK kinase kinase 6; MEKKK6; MGC21111; MINK 1; MINK; Misshapen like kinase 1; Misshapen NIKs Related kinase; Misshapen/NIK related kinase; Mitogen activated protein kinase kinase kinase kinase 6; RP23-122P1.6; Ysk2; ZC3; MINK1 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for MINK1 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MINK1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 68161546
• NCBI GeneID: 50488
• NCBI Accession #: NP_001020108.1
• NCBI GenBank Nucleotide #: NM_001024937.3
• UniProt Accession #: Q8N4C8; Q5U8Z0; Q9P1X1; Q9P2R8; D3DTK3; D3DTK4
• Molecular Weight: 149,822 Da
• NCBI Official Full Name: misshapen-like kinase 1 isoform 4
• NCBI Official Synonym Full Names: misshapen-like kinase 1
• NCBI Official Symbol: MINK1
• NCBI Official Synonym Symbols: B55; ZC3; MINK; YSK2; hMINK; MAP4K6; hMINKbeta
• NCBI Protein Information: misshapen-like kinase 1; MEKKK 6; MEK kinase kinase 6; GCK family kinase MINK; misshapen/NIK-related kinase; MAPK/ERK kinase kinase kinase 6; serine/threonine protein kinase; mitogen-activated protein kinase kinase kinase kinase 6
• UniProt Protein Name: Misshapen-like kinase 1
• Protein Family: Misshapen-like kinase
• UniProt Gene Name: MINK1
• UniProt Synonym Gene Names: B55; MAP4K6; MINK; YSK2; ZC3; MEK kinase kinase 6; MEKKK 6
• UniProt Entry Name: MINK1_HUMAN

NCBI Description

This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

MINK: a protein kinase of the STE20 family. Studies of the mouse ortholog indicate increased expression during postnatal mouse cerebral development. Activates JNK and the p38 pathways. Three splicing isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; EC 2.7.11.1; STE group; STE20 family; MSN subfamily

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: Golgi apparatus; postsynaptic membrane; axon; dendrite; cytoplasm; postsynaptic density; cell junction; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity

Biological Process: regulation of cell-matrix adhesion; multicellular organismal development; protein amino acid autophosphorylation; dendrite morphogenesis; positive regulation of JNK cascade; negative thymic T cell selection; regulation of cell migration; protein amino acid phosphorylation; microvillus biogenesis; synaptic transmission; regulation of cell-cell adhesion; regulation of catalytic activity; actin cytoskeleton reorganization; JNK cascade; response to stress