HABP2 blocking peptide

HABP2 Antibody (C-term) Blocking peptide

• Gene Names: HABP2; FSAP; HABP; PHBP; HGFAL; NMTC5
• Synonyms: HABP2; HABP2 Antibody (C-term) Blocking peptide; Hyaluronan-binding protein 2; 3421-; Factor VII-activating protease; Factor seven-activating protease; FSAP; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding protein; Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form; HGFAL; PHBP; HABP2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 560

• Cellular Location: Secreted. Note: Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form
• Tissue Location: Ubiquitously expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HABP2 blocking peptide

Cleaves the alpha-chain at multiple sites and the beta- chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII.

NCBI and Uniprot Product Information

• NCBI GI #: 4758502
• NCBI GeneID: 3026
• NCBI Accession #: NP_004123
• NCBI GenBank Nucleotide #: NM_004132.4
• UniProt Accession #: Q14520; O00663; A8K467; B7Z8U5; F5H5M6
• Molecular Weight: 59,864 Da
• NCBI Official Full Name: hyaluronan-binding protein 2 isoform 1 preproprotein
• NCBI Official Synonym Full Names: hyaluronan binding protein 2
• NCBI Official Symbol: HABP2
• NCBI Official Synonym Symbols: FSAP; HABP; PHBP; HGFAL; NMTC5
• NCBI Protein Information: hyaluronan-binding protein 2
• UniProt Protein Name: Hyaluronan-binding protein 2
• Protein Family: Hyaluronan-binding protein
• UniProt Gene Name: HABP2
• UniProt Synonym Gene Names: HGFAL; PHBP; FSAP
• UniProt Entry Name: HABP2_HUMAN

NCBI Description

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Description

HABP2: Cleaves the alpha-chain at multiple sites and the beta- chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII. Belongs to the peptidase S1 family.

Protein type: Secreted; Secreted, signal peptide; EC 3.4.21.-; Protease; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q25.3

Cellular Component: extracellular space

Molecular Function: glycosaminoglycan binding

Biological Process: cell adhesion

Disease: Thrombophilia Due To Thrombin Defect; Thyroid Cancer, Nonmedullary, 5