DYRK2 blocking peptide

DYRK2 Peptide

Cat. Num. AAA152914

• Applications: Blocking (BL)
• Synonyms: DYRK2; DYRK2 Peptide; Dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; DYRK2 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 528

• Applicable Applications for DYRK2 blocking peptide: Blocking (BL)
• Application Notes: DYRK2 peptide is used for blocking the activity of DYRK2 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 18 amino acids near the carboxy terminus of human DYRK2.
• Preparation and Storage: Store DYRK2 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 4503427
• NCBI GeneID: 8445
• NCBI Accession #: NP_006473
• NCBI GenBank Nucleotide #: NM_003583.3
• UniProt Accession #: Q92630; Q9BRB5; B2R9V9
• Molecular Weight: 59,715 Da
• NCBI Official Full Name: dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 1
• NCBI Official Synonym Full Names: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
• NCBI Official Symbol: DYRK2
• NCBI Protein Information: dual specificity tyrosine-phosphorylation-regulated kinase 2
• UniProt Protein Name: Dual specificity tyrosine-phosphorylation-regulated kinase 2
• Protein Family: Dual specificity tyrosine-phosphorylation-regulated kinase
• UniProt Gene Name: DYRK2
• UniProt Entry Name: DYRK2_HUMAN

NCBI Description

DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]

Uniprot Description

DYRK2: a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Phosphorylates the translation initiation factor eIF2B at Ser539, priming it for phosphorylation by glycogen synthase kinase-3.

Protein type: Protein kinase, dual-specificity (non-receptor); Protein kinase, CMGC; EC 2.7.12.1; Kinase, protein; CMGC group; DYRK family; Dyrk2 subfamily

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: nucleoplasm; cytoplasm; nucleus; ribonucleoprotein complex; ubiquitin ligase complex

Molecular Function: protein serine/threonine kinase activity; protein binding; ubiquitin binding; protein-tyrosine kinase activity; manganese ion binding; protein serine/threonine/tyrosine kinase activity; magnesium ion binding; ATP binding

Biological Process: smoothened signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of glycogen biosynthetic process; negative regulation of NFAT protein import into nucleus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; protein amino acid phosphorylation; response to DNA damage stimulus