Mouse ataxia telangiectasia mutated ELISA Kit | ATM elisa kit
Mouse Serine-protein kinase ATM, ATM ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ATM: an atypical kinase of the PIKK family. Regulates cell cycle checkpoints and DNA repair . May function as a tumor suppressor. Activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Involved in the activation of ABL1 and SAPK. Binds DNA ends and is part of the BRCA1- associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. LOF mutations associated with ataxia telangiectasia, causing progressive loss of motor control (ataxia), dilation of superficial blood vessels (telangiectasia), cancer and immune deficiency. Approximately 30% of cases develop tumors, mostly lymphomas and leukemias, due to defects in DNA damage repair. Somatic mutations seen in leukemias and lymphomas.
Protein type: EC 2.7.11.1; Tumor suppressor; DNA repair, damage; Protein kinase, atypical; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; ATYPICAL group; PIKK family
Cellular Component: chromosome, telomeric region; cytoplasm; spindle; cytoplasmic vesicle; intracellular; nucleus
Molecular Function: protein dimerization activity; 1-phosphatidylinositol-3-kinase activity; nucleotide binding; protein N-terminus binding; DNA-dependent protein kinase activity; histone serine kinase activity; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; DNA binding; transferase activity, transferring phosphorus-containing groups; protein complex binding; kinase activity; phosphotransferase activity, alcohol group as acceptor; ATP binding
Biological Process: lipoprotein catabolic process; DNA damage induced protein phosphorylation; regulation of cell cycle; positive regulation of apoptosis; protein amino acid autophosphorylation; histone phosphorylation; heart development; pre-B cell allelic exclusion; negative regulation of B cell proliferation; determination of adult life span; protein amino acid phosphorylation; phosphoinositide phosphorylation; positive regulation of neuron apoptosis; mitotic cell cycle spindle assembly checkpoint; cell cycle arrest; telomere maintenance; somitogenesis; V(D)J recombination; female gamete generation; DNA repair; cell cycle; double-strand break repair via homologous recombination; neuron apoptosis; peptidyl-serine phosphorylation; DNA damage response, signal transduction resulting in induction of apoptosis; DNA damage checkpoint; response to hypoxia; positive regulation of DNA damage response, signal transduction by p53 class mediator; response to ionizing radiation; brain development; response to DNA damage stimulus; phosphorylation; oocyte development
Research Articles on ATM
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Product Notes
The Mouse ATM atm (Catalog #AAA9321644) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9321644 ELISA Kit recognizes Mouse ATM. It is sometimes possible for the material contained within the vial of "ataxia telangiectasia mutated, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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