Putative Polycomb group protein ASXL3 (ASXL3) Recombinant Protein | ASXL3 recombinant protein

Recombinant Human Putative Polycomb group protein ASXL3 (ASXL3) , partial

• Gene Names: ASXL3; BRPS; KIAA1713
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Putative Polycomb group protein ASXL3 (ASXL3); Recombinant Human Putative Polycomb group protein ASXL3 (ASXL3); partial; ASXL3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 317

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 149944526
• NCBI GeneID: 80816
• NCBI Accession #: NP_085135.1
• NCBI GenBank Nucleotide #: NM_030632.2
• UniProt Accession #: Q9C0F0; Q6ZMX6; Q96MU3; Q9UFC5
• Molecular Weight: 34,901 Da
• NCBI Official Full Name: putative Polycomb group protein ASXL3
• NCBI Official Synonym Full Names: additional sex combs like 3, transcriptional regulator
• NCBI Official Symbol: ASXL3
• NCBI Official Synonym Symbols: BRPS; KIAA1713
• NCBI Protein Information: putative Polycomb group protein ASXL3
• UniProt Protein Name: Putative Polycomb group protein ASXL3
• Protein Family: Putative Polycomb group protein
• UniProt Gene Name: ASXL3
• UniProt Synonym Gene Names: KIAA1713

NCBI Description

This gene encodes a protein containing a plant homeodomain (PHD) zinc finger domain that plays a role in the regulation of gene transcription. The encoded protein has been shown to negatively regulate lipogenesis by binding to and inhibiting the transcriptional activity of two nuclear hormone receptors, oxysterols receptor LXR-alpha (LXRalpha) and thyroid hormone receptor beta (TRbeta). The encoded protein may also inhibit histone deubiquitination. Mutations in this gene have been identified in human patients with Bainbridge-Ropers syndrome, which is characterized by feeding difficulties, developmental delay and other features. [provided by RefSeq, May 2017]

Uniprot Description

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility ().