Vacuolar aminopeptidase 1 (LAP4) Recombinant Protein | LAP4 recombinant protein
Recombinant Saccharomyces cerevisiae Vacuolar aminopeptidase 1 (LAP4)
NCBI and Uniprot Product Information
Uniprot Description
Resident vacuolar enzyme that catalyzes the removal of amino acids from the N-terminus of peptides and proteins. Also acts as the major cargo protein of the cytoplasm-to-vacuole targeting (Cvt) pathway. The precursor form of aminopeptidase 1 (prApe1) assembles into dodecamers and the propeptide mediates the aggregation of dodecamers into higher multimers. The multimers are then recognized via the propeptide by their receptor ATG19, and ATG19 further interacts with ATG11, which tethers the APE1-ATG19 complex to the pre-autophagosomal structure (PAS). The cargo-receptor complex (also Cvt complex) is selectively enwrapped by a double-membrane structure termed the Cvt vesicle under vegetative growth conditions and by a similar but larger double-membrane structure termed the autophagosome under nitrogen starvation conditions. The Cvt vesicle or the autophagosome fuses with the vacuolar membrane and release its content in the vacuolar lumen. In the vacuole, prApe1 is processed into mature aminopeptidase 1 (mApe1).
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Product Notes
The LAP4 ape1 (Catalog #AAA1091586) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 46-514, full length protein. The amino acid sequence is listed below: EHNYEDIAQE FIDFIYKNPT TYHVVSFFAE LLDKHNFKYL SEKSNWQDSI GEDGGKFYTI RNGTNLSAFI LGKNWRAEKG VGVIGSHVDA LTVKLKPVSF KDTAEGYGRI AVAPYGGTLN ELWLDRDLGI GGRLLYKKKG TNEIKSALVD STPLPVCRIP SLAPHFGKPA EGPFDKEDQT IPVIGFPTPD EEGNEPPTDD EKKSPLFGKH CIHLLRYVAK LAGVEVSELI QMDLDLFDVQ KGTIGGIGKH FLFAPRLDDR LCSFAAMIAL ICYAKDVNTE ESDLFSTVTL YDNEEIGSLT RQGAKGGLLE SVVERSSSAF TKKPVDLHTV WANSIILSAD VNHLYNPNFP EVYLKNHFPV PNVGITLSLD PNGHMATDVV GTALVEELAR RNGDKVQYFQ IKNNSRSGGT IGPSLASQTG ARTIDLGIAQ LSMHSIRAAT GSKDVGLGVK FFNGFFKHWR SVYDEFGEL. It is sometimes possible for the material contained within the vial of "Vacuolar aminopeptidase 1 (LAP4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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