Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) Recombinant Protein | ALPL recombinant protein
Recombinant Chicken Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Alkaline phosphatase; tissue-nonspecific isozyme (ALPL); Recombinant Chicken Alkaline phosphatase; ALPL recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
17-498, Full length protein
Sequence
LVPEREKDPEYWRQQAQETLRDALRLQHLNQNVAKNLILFLGDGMGVSTVTAARILKGQLQHRKGEESLLEMDKFPYVALAKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAGVTRDRCNTTKGQEVTSILRWAKDEGKAVGIVTTTRVTHATPSAAYAHSANRDWYSDGEMPLDALEGGCKDIARQLVDNIPDIEVILGGGRKYMFPKNTSDVEYPQEERHRGTRLDGKDLVQAWHDTKPAGKVAKYVWHRRELLALNVSRVDFLLGLFEPGDMVYELDRNNETDPSLSEMVAVAIRMLQKNPRGFFLLVEGGRIDHGHHEGKAKQALHEAVELDRAVGLAGRLTSPRDTLSVVTADHSHVFTFGGYTPRGNPIFGLAPMQSDVDRKPFTSILYGNGPGYKIVGGERENVSAVDFAHANYQAQAAVPLRQETHGGEDVAVFARGPMAHLLHGVDEQNYIPHAMAYAACIGPNRAHCSS
Sequence Length
482
Species
Chicken
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for ALPL recombinant protein
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver
bone
kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
bone
kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
56,760 Da
NCBI Official Full Name
alkaline phosphatase, tissue-nonspecific isozyme
NCBI Official Synonym Full Names
alkaline phosphatase, liver/bone/kidney
NCBI Official Symbol
ALPL
NCBI Protein Information
alkaline phosphatase, tissue-nonspecific isozyme
UniProt Protein Name
Alkaline phosphatase, tissue-nonspecific isozyme
Protein Family
UniProt Gene Name
ALPL
UniProt Synonym Gene Names
AP-TNAP; TNSALP
Uniprot Description
This isozyme may play a role in skeletal mineralization.
Research Articles on ALPL
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Product Notes
The ALPL alpl (Catalog #AAA1425153) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 17-498, Full length protein. The amino acid sequence is listed below: LVPEREKDPE YWRQQAQETL RDALRLQHLN QNVAKNLILF LGDGMGVSTV TAARILKGQL QHRKGEESLL EMDKFPYVAL AKTYNTNAQV PDSAGTATAY LCGVKANEGT VGVSAGVTRD RCNTTKGQEV TSILRWAKDE GKAVGIVTTT RVTHATPSAA YAHSANRDWY SDGEMPLDAL EGGCKDIARQ LVDNIPDIEV ILGGGRKYMF PKNTSDVEYP QEERHRGTRL DGKDLVQAWH DTKPAGKVAK YVWHRRELLA LNVSRVDFLL GLFEPGDMVY ELDRNNETDP SLSEMVAVAI RMLQKNPRGF FLLVEGGRID HGHHEGKAKQ ALHEAVELDR AVGLAGRLTS PRDTLSVVTA DHSHVFTFGG YTPRGNPIFG LAPMQSDVDR KPFTSILYGN GPGYKIVGGE RENVSAVDFA HANYQAQAAV PLRQETHGGE DVAVFARGPM AHLLHGVDEQ NYIPHAMAYA ACIGPNRAHC SS. It is sometimes possible for the material contained within the vial of "Alkaline phosphatase, tissue-nonspecific isozyme (ALPL), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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