Phosphoinositide 3-Kinase beta, p110 beta, p85 alpha Active Protein | PIK3R2 active protein
Phosphoinositide 3-Kinase beta, p110 beta, p85 alpha, Recombinant, Human (PI3K)
Phosphoinositide 3-kinases (PI3Ks) phosphorylate phosphatidylinositols (PIs) at their 3´-OH position generating lipid second messengers and thereby regulate numeroMyBioSource processes including cell growth, differentiation, survival, proliferation, migration and metabolism. On the basis of structural similarities and substrate specificity, the PI3K family can be subdivided into three classes termed I, II, and III. All human class I members are heterodimers consisting of a catalytic subunit (MW approx. 110kD) and a noncatalytic subunit (MW 50, 55, 85, or 101kD) and are known to phosphorylate phosphatidylinositol (PI), phosphatidylinositol-4-mono-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2) in vitro. The class I members can be further subdivided into class IA and IB PI3Ks. Class IA exists in three isoforms p110, p110 and p110) whereas the only class IB member is termed p110. Class IA PI3Ks are activated by adaptor proteins such as Ras or BCAP, or -kinase-associated receptors including antigen, co-stimulatory and cytokine receptors e.g. CD19, CD28, Insulin receptor, EGFR, and PDGFR). p110 is activated by G-protein-coupled receptors (GPCRs). Effectors of class I PI3Ks are pleckstrin-homology domain proteins such as Akt/PKB, BTK, TEC, ITK, BAM32, and small GTPases (e.g. Cdc42, Rac, or Ras). The action of PI3Ks is regulated by the phosphatidylinositol- 3,4,5-trisphosphate phosphatases SHIP and PTEN.
NCBI and Uniprot Product Information
p85a: 83.6kD
NCBI Description
Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Description
PIK3R2: regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Its SH2 domains interacts with the YTHM motif of phosphorylated INSR in vitro. Defects in PIK3R1 are a cause of severe insulin resistance. Four alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Kinase, lipid
Chromosomal Location of Human Ortholog: 19q13.2-q13.4
Cellular Component: cytosol; nucleus; phosphoinositide 3-kinase complex
Molecular Function: protein binding; protein heterodimerization activity; 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase regulator activity; receptor tyrosine kinase binding; protein phosphatase binding
Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; T cell receptor signaling pathway; regulation of phosphoinositide 3-kinase activity; regulation of small GTPase mediated signal transduction; protein transport; cellular response to insulin stimulus; phospholipid metabolic process; small GTPase mediated signal transduction; insulin receptor signaling pathway; phosphatidylinositol biosynthetic process; positive regulation of transcription factor import into nucleus; innate immune response; cell glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter; regulation of autophagy; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration
Disease: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus Syndrome 1
Research Articles on PIK3R2
Similar Products
Product Notes
The PIK3R2 pik3r2 (Catalog #AAA636546) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Phosphoinositide 3-Kinase beta, p110 beta, p85 alpha, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
