Tyrosine-protein kinase Fyn (Fyn) Recombinant Protein | Fyn recombinant protein
Recombinant Mouse Tyrosine-protein kinase Fyn (Fyn)
NCBI and Uniprot Product Information
Uniprot Description
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1 ().
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Product Notes
The Fyn fyn (Catalog #AAA967186) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-537, Full length protein. The amino acid sequence is listed below: GCVQCKDKEA AKLTEERDGS LNQSSGYRYG TDPTPQHYPS FGVTSIPNYN NFHAAGGQGL TVFGGVNSSS HTGTLRTRGG TGVTLFVALY DYEARTEDDL SFHKGEKFQI LNSSEGDWWE ARSLTTGETG YIPSNYVAPV DSIQAEEWYF GKLGRKDAER QLLSFGNPRG TFLIRESETT KGAYSLSIRD WDDMKGDHVK HYKIRKLDNG GYYITTRAQF ETLQQLVQHY SERAAGLCCR LVVPCHKGMP RLTDLSVKTK DVWEIPRESL QLIKRLGNGQ FGEVWMGTWN GNTKVAIKTL KPGTMSPESF LEEAQIMKKL KHDKLVQLYA VVSEEPIYIV TEYMSKGSLL DFLKDGEGRA LKLPNLVDMA AQVAAGMAYI ERMNYIHRDL RSANILVGNG LICKIADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALYG RFTIKSDVWS FGILLTELVT KGRVPYPGMN NREVLEQVER GYRMPCPQDC PISLHELMIH CWKKDPEERP TFEYLQGFLE DYFTATEPQY QPGENL. It is sometimes possible for the material contained within the vial of "Tyrosine-protein kinase Fyn (Fyn), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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