Human Lens Fiber Major Intrinsic Protein (MIP) ELISA Kit | MIP elisa kit

Human Lens Fiber Major Intrinsic Protein (MIP) ELISA Kit

Cat. Num. AAA9354758

• Gene Names: MIP; AQP0; LIM1; MP26; MIP26; CTRCT15
• Reactivity: Human
• Synonyms: Lens Fiber Major Intrinsic Protein (MIP); Human Lens Fiber Major Intrinsic Protein (MIP) ELISA Kit; MIP elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples.
• Assay Type: Sandwich
• Detection Range: 3.12 ng/ml - 100 ng/ml.
• Sensitivity: 1.0 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for MIP elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of MIP (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 6912506
• NCBI GeneID: 4284
• NCBI Accession #: NP_036196.1
• NCBI GenBank Nucleotide #: NM_012064.3
• Molecular Weight: 28,122 Da
• NCBI Official Full Name: lens fiber major intrinsic protein
• NCBI Official Synonym Full Names: major intrinsic protein of lens fiber
• NCBI Official Symbol: MIP
• NCBI Official Synonym Symbols: AQP0; LIM1; MP26; MIP26; CTRCT15
• NCBI Protein Information: lens fiber major intrinsic protein
• UniProt Protein Name: Lens fiber major intrinsic protein
• Protein Family: Lens fiber major intrinsic protein
• UniProt Gene Name: MIP
• UniProt Synonym Gene Names: AQP0; MP26
• UniProt Entry Name: MIP_HUMAN

NCBI Description

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]

Uniprot Description

AQP0: major intrinsic protein of lens fiber. A member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. May be responsible for regulating the osmolarity of the lens. Defects in MIP are a cause of autosomal recessive congenital cataract.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, misc.; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: apical plasma membrane; gap junction; integral to plasma membrane; intracellular canaliculus; intracellular membrane-bound organelle; plasma membrane

Molecular Function: calmodulin binding; glycerol channel activity; structural constituent of eye lens; transporter activity; water channel activity

Biological Process: canalicular bile acid transport; glycerol transport; lens development in camera-type eye; response to stimulus; transmembrane transport; visual perception; water transport

Disease: Cataract 15, Multiple Types