Human soc-2 suppressor of clear homolog (C. elegans) ELISA Kit | SHOC2 elisa kit
Human Leucine-rich repeat protein SHOC-2, SHOC2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]
Uniprot Description
SHOC2: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. Defects in SHOC2 are the cause of Noonan syndrome-like disorder with loose anagen hair (NSLH). A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair. Belongs to the SHOC2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 10q25
Cellular Component: nucleoplasm; cytoplasm; protein phosphatase type 1 complex; nucleus
Molecular Function: protein phosphatase regulator activity; protein phosphatase binding
Biological Process: fibroblast growth factor receptor signaling pathway; regulation of catalytic activity; Ras protein signal transduction; positive regulation of Ras protein signal transduction
Disease: Noonan Syndrome-like Disorder With Loose Anagen Hair
Research Articles on SHOC2
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Product Notes
The Human SHOC2 shoc2 (Catalog #AAA9326353) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326353 ELISA Kit recognizes Human SHOC2. It is sometimes possible for the material contained within the vial of "soc-2 suppressor of clear homolog (C. elegans), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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