Mouse potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) ELISA Kit | KCNA1 elisa kit
Mouse Potassium voltage-gated channel subfamily A member 1, KCNA1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Kv1.1: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Defects in KCNA1 are the cause of episodic ataxia type 1 (EA1); also known as paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent. Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1). Myokymia is a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium
Cellular Component: voltage-gated potassium channel complex; cell surface; integral to plasma membrane; endoplasmic reticulum; dendrite; paranode region of axon; integral to membrane; cytosol; presynaptic membrane; cell projection; membrane; cell soma; axon; apical plasma membrane; plasma membrane; synapse; nerve terminal; cytoplasmic vesicle; cell junction
Molecular Function: voltage-gated potassium channel activity; potassium channel activity; delayed rectifier potassium channel activity; ion channel activity; voltage-gated ion channel activity
Biological Process: startle response; regulation of muscle contraction; neuromuscular process; hippocampus development; generation of action potential; detection of mechanical stimulus involved in sensory perception of pain; regulation of membrane potential; transport; neuroblast proliferation; ion transport; brain development; transmembrane transport; protein homooligomerization; potassium ion transport; detection of mechanical stimulus involved in sensory perception of touch
Research Articles on KCNA1
Similar Products
Product Notes
The Mouse KCNA1 kcna1 (Catalog #AAA9325318) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325318 ELISA Kit recognizes Mouse KCNA1. It is sometimes possible for the material contained within the vial of "potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
