Mouse SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) ELISA Kit | SNF8 elisa kit
Mouse Vacuolar-sorting protein SNF8, SNF8 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SNF8: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Belongs to the SNF8 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor
Cellular Component: nucleoplasm; transcription factor complex; membrane; cytoplasm; nucleus; endosome
Molecular Function: protein homodimerization activity; transcription factor binding
Biological Process: regulation of transcription from RNA polymerase II promoter; protein transport; transcription, DNA-dependent; regulation of transcription, DNA-dependent; transport; protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway
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Product Notes
The Mouse SNF8 snf8 (Catalog #AAA9323280) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9323280 ELISA Kit recognizes Mouse SNF8. It is sometimes possible for the material contained within the vial of "SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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