Rat karyopherin (importin) beta 1 ELISA Kit | KPNB1 elisa kit
Rat Importin subunit beta-1, KPNB1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
subunit of complex necessary for nuclear import [RGD, Feb 2006]
Uniprot Description
KPNB1: a nuclear import protein nuclear protein import that functions either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleus. Forms a complex with an importin alpha subunit. Forms a heterodimer with IPO7. Interacts with IPO7, SNUPN, RPL23A and XPO1. Two isoforms of the human protein have been reported. Belongs to the importin beta family.
Protein type: Nuclear import; Karyopherin
Cellular Component: nucleoplasm; nuclear membrane; protein complex; membrane; cell; cytoplasm; nuclear envelope; intracellular
Molecular Function: protein domain specific binding; protein binding; enzyme binding; Ran GTPase binding; protein transporter activity
Biological Process: intracellular protein transport; ribosomal protein import into nucleus; protein import into nucleus; nucleocytoplasmic transport
Research Articles on KPNB1
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Product Notes
The Rat KPNB1 kpnb1 (Catalog #AAA9321273) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9321273 ELISA Kit recognizes Rat KPNB1. It is sometimes possible for the material contained within the vial of "karyopherin (importin) beta 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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