Mouse gamma-aminobutyric acid (GABA) A receptor, beta 3 ELISA Kit | GABRB3 elisa kit
Mouse Gamma-aminobutyric acid receptor subunit beta-3, GABRB3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
GABRB3: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Defects in GABRB3 are associated with chronic insomnia, a condition of inability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition. Defects in GABRB3 are the cause of childhood absence epilepsy type 5 (ECA5). ECA5 is a subtype of idiopathic generalized epilepsy (IGE) characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Absence seizures may either remit or persist into adulthood. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Transporter; Transporter, ion channel; Channel, chloride; Membrane protein, integral; Channel, ligand-gated
Cellular Component: postsynaptic membrane; membrane; integral to plasma membrane; integral to membrane; plasma membrane; terminal button; synapse; cell junction
Molecular Function: chloride channel activity; GABA-A receptor activity; ion channel activity; extracellular ligand-gated ion channel activity; GABA-gated chloride ion channel activity
Biological Process: sensory perception of sound; transport; inner ear receptor cell development; regulation of neuron apoptosis; synaptic transmission, GABAergic; neuron development; chloride transport; ion transport; negative regulation of neuron apoptosis; palate development; signal transduction; gamma-aminobutyric acid signaling pathway
Research Articles on GABRB3
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Product Notes
The Mouse GABRB3 gabrb3 (Catalog #AAA9318306) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318306 ELISA Kit recognizes Mouse GABRB3. It is sometimes possible for the material contained within the vial of "gamma-aminobutyric acid (GABA) A receptor, beta 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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