Rat NEDD8 activating enzyme E1 subunit 1 ELISA Kit | NAE1 elisa kit
Rat NEDD8-activating enzyme E1 regulatory subunit, NAE1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
may induce apoptosis [RGD, Feb 2006]
Uniprot Description
APPBP1: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation
Protein type: Ubiquitin conjugating system
Cellular Component: plasma membrane; cytosol; nucleus
Molecular Function: NEDD8 activating enzyme activity; protein heterodimerization activity; ubiquitin protein ligase binding
Biological Process: regulation of apoptosis; neuron apoptosis; protein neddylation; apoptosis; metabolic process; regulation of neuron apoptosis; mitotic cell cycle DNA replication checkpoint
Research Articles on NAE1
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Product Notes
The Rat NAE1 nae1 (Catalog #AAA9317147) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317147 ELISA Kit recognizes Rat NAE1. It is sometimes possible for the material contained within the vial of "NEDD8 activating enzyme E1 subunit 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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