SKA2 blocking peptide

SKA2 Antibody (N-term) Blocking peptide

• Gene Names: SKA2; FAM33A
• Synonyms: SKA2; SKA2 Antibody (N-term) Blocking peptide; Spindle and kinetochore-associated protein 2; Protein FAM33A; FAM33A; SKA2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 121

• Cellular Location: Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note: Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SKA2 blocking peptide

Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization.

NCBI and Uniprot Product Information

• NCBI GI #: 74762633
• NCBI GeneID: 348235
• UniProt Accession #: Q8WVK7; A6NIL3; B3KPL3; E9PCB8
• Molecular Weight: 8,282 Da
• NCBI Official Full Name: Spindle and kinetochore-associated protein 2
• NCBI Official Synonym Full Names: spindle and kinetochore associated complex subunit 2
• NCBI Official Symbol: SKA2
• NCBI Official Synonym Symbols: FAM33A
• NCBI Protein Information: spindle and kinetochore-associated protein 2
• UniProt Protein Name: Spindle and kinetochore-associated protein 2
• Protein Family: Spindle and kinetochore-associated protein
• UniProt Gene Name: SKA2
• UniProt Synonym Gene Names: FAM33A
• UniProt Entry Name: SKA2_HUMAN

Uniprot Description

Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).