Rabbit anti-Human CARD10 Polyclonal Antibody | anti-CARD10 antibody
CARD10 Antibody (Center)
that consists of 6 or 7 antiparallel alpha helices. It participates
in apoptosis signaling through highly specific protein-protein
homophilic interactions. Like several other CARD proteins, CARD10
belongs to the membrane-associated guanylate kinase (MAGUK) family
and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM
603517) (Wang et al., 2001 [PubMed 11259443]).
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Rehman, A.O., et al. Int J Oral Sci 1(3):105-118(2009)
Martin, D., et al. J. Biol. Chem. 284(10):6038-6042(2009)
NCBI and Uniprot Product Information
NCBI Description
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]
Uniprot Description
CARD10: a protein containing a caspase recruitment domain (CARD) that functions as an activator of BCL10 and NF-kappaB signaling. CARD is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. CARD proteins function as scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. The CARD domain of CARD14 associates specifically with the CARD domains of CARD10 and BCL10, a signaling protein that activates NF-kB through the IkappaB kinase complex in response to upstream stimuli. When expressed in cells, CARD14 activates NF-kappaB and induces the phosphorylation of BCL10. A subgroup of primary lymphomas of the central nervous system have higher levels of CARD14 expression.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: CBM complex; cytoplasm
Molecular Function: protein binding; receptor signaling complex scaffold activity
Biological Process: regulation of apoptosis; activation of NF-kappaB-inducing kinase; protein complex assembly