CD74 recombinant protein
Recombinant Mouse CD74 Protein
Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.
NCBI and Uniprot Product Information
Uniprot Description
CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine; Endoplasmic reticulum
Cellular Component: Golgi apparatus; multivesicular body; cell surface; membrane; integral to plasma membrane; lysosome; endoplasmic reticulum; late endosome; plasma membrane; integral to membrane; vacuole; intracellular; external side of plasma membrane; MHC class II protein complex
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; beta-amyloid binding; cytokine binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase binding; MHC class II protein binding
Biological Process: protein folding; activation of MAPK activity; positive regulation of dendritic cell antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; defense response; prostaglandin biosynthetic process; signal transduction; negative regulation of T cell differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; intracellular protein transport; positive regulation of fibroblast proliferation; negative regulation of mature B cell apoptosis; positive regulation of innate immune response; positive regulation of B cell proliferation; protein complex assembly; positive regulation of adaptive immune response; positive thymic T cell selection; negative regulation of peptide secretion; positive regulation of T-helper 2 type immune response; chaperone cofactor-dependent protein folding; immune system process; cytokine and chemokine mediated signaling pathway; negative thymic T cell selection; antigen processing and presentation; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; immune response; immunoglobulin mediated immune response; positive regulation of cytokine and chemokine mediated signaling pathway; negative regulation of apoptosis
Research Articles on CD74
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Product Notes
The CD74 cd74 (Catalog #AAA8305215) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CD74 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), SDS-PAGE. Researchers should empirically determine the suitability of the CD74 cd74 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: QQQGRLDKLT ITSQNLQLES LRMKLPKSAK PVSQMRMATP LLMRPMSMDN MLLGPVKNVT KYGNMTQDHV MHLLTRSGPL EYPQLKGTFP ENLKHLKNSM DGVNWKIFES WMKQWLLFEM SKNSLEEKKP TEAPPKEPLD MEDLSSGLGV TRQELGQVTL VDHHHHHH. It is sometimes possible for the material contained within the vial of "CD74, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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