GADD45 beta Blocking Peptide | GADD45B blocking peptide

GADD45 beta Blocking Peptide

Cat. Num. AAA823825

• Gene Names: GADD45B; MYD118; GADD45BETA
• Reactivity: Human, Mouse, Rat, Bovine, Monkey
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: GADD45 beta; GADD45 beta Blocking Peptide; MYD118; Growth arrest and DNA damage-inducible protein GADD45 beta; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118; GADD45B blocking peptide

• Host: Synthetic
• Reactivity: Human, Mouse, Rat, Bovine, Monkey
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 160

• Applicable Applications for GADD45B blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for GADD45B blocking peptide

The peptide is used to block Anti-GADD45 beta Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 86991436
• NCBI GeneID: 4616
• NCBI Accession #: NP_056490.2
• NCBI GenBank Nucleotide #: NM_015675.3
• UniProt Accession #: O75293; O75960; Q17R46; A8KAM2
• Molecular Weight: 17,818 Da
• NCBI Official Full Name: growth arrest and DNA damage-inducible protein GADD45 beta
• NCBI Official Synonym Full Names: growth arrest and DNA-damage-inducible, beta
• NCBI Official Symbol: GADD45B
• NCBI Official Synonym Symbols: MYD118; GADD45BETA
• NCBI Protein Information: growth arrest and DNA damage-inducible protein GADD45 beta; negative growth regulatory protein MyD118; myeloid differentiation primary response protein MyD118
• UniProt Protein Name: Growth arrest and DNA damage-inducible protein GADD45 beta
• Protein Family: Growth arrest and DNA damage-inducible protein
• UniProt Gene Name: GADD45B
• UniProt Synonym Gene Names: MYD118
• UniProt Entry Name: GA45B_HUMAN

NCBI Description

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

Uniprot Description

GADD45B: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Belongs to the GADD45 family.

Protein type: Apoptosis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: activation of MAPKK activity; positive regulation of apoptosis; apoptosis; regulation of cell cycle; multicellular organismal development; activation of MAPKKK activity; positive regulation of JNK cascade; negative regulation of protein kinase activity; response to stress; cell differentiation