ATP6AP1 blocking peptide

ATP6AP1 Blocking Peptide

Cat. Num. AAA823361

• Gene Names: ATP6AP1; 16A; CF2; Ac45; XAP3; XAP-3; ATP6S1; VATPS1; ATP6IP1
• Reactivity: Human, Mouse, Rat, Bovine, Pig
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: ATP6AP1; ATP6AP1 Blocking Peptide; ATP6IP1; ATP6S1; VATPS1; XAP3; V-type proton ATPase subunit S1; V-ATPase subunit S1; Protein XAP-3; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; Vacuolar proton pump subunit S1; ATP6AP1 blocking peptide

• Host: Synthetic
• Reactivity: Human, Mouse, Rat, Bovine, Pig
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 470

• Applicable Applications for ATP6AP1 blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for ATP6AP1 blocking peptide

The peptide is used to block Anti-ATP6AP1 Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 17136148
• NCBI GeneID: 537
• NCBI Accession #: NP_001174.2
• NCBI GenBank Nucleotide #: NM_001183.5
• UniProt Accession #: Q15904; Q8NBT4; Q9H0C7; A6ZKI4
• Molecular Weight: 52,026 Da
• NCBI Official Full Name: V-type proton ATPase subunit S1
• NCBI Official Synonym Full Names: ATPase, H+ transporting, lysosomal accessory protein 1
• NCBI Official Symbol: ATP6AP1
• NCBI Official Synonym Symbols: 16A; CF2; Ac45; XAP3; XAP-3; ATP6S1; VATPS1; ATP6IP1
• NCBI Protein Information: V-type proton ATPase subunit S1; protein XAP-3; H-ATPase subunit; V-ATPase subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; vacuolar proton pump subunit S1; ATPase, H+ transporting, lysosomal interacting protein 1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1
• UniProt Protein Name: V-type proton ATPase subunit S1
• Protein Family: V-type proton ATPase
• UniProt Gene Name: ATP6AP1
• UniProt Synonym Gene Names: ATP6IP1; ATP6S1; VATPS1; XAP3; V-ATPase subunit S1
• UniProt Entry Name: VAS1_HUMAN

NCBI Description

This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]

Uniprot Description

ATP6AP1: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the vacuolar ATPase subunit S1 family.

Protein type: Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Hydrolase; EC 3.6.3.14; Transporter

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: vacuolar membrane; integral to membrane; endosome membrane; proton-transporting two-sector ATPase complex

Molecular Function: transporter activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; hydrogen ion transporting ATPase activity, rotational mechanism; ATP binding; Rab GTPase binding

Biological Process: positive regulation of osteoblast differentiation; proton transport; cellular iron ion homeostasis; pH reduction; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; positive regulation of bone resorption; transmembrane transport; establishment of organelle localization; positive regulation of exocytosis