Rabbit STK3 Polyclonal Antibody | anti-STK3 antibody

Rabbit anti-Danio rerio (Zebrafish)(Brachydanio rerio) STK3 Polyclonal Antibody

• Gene Names: stk3; zgc:55383; wu:fc19e11
• Reactivity: Danio rerio (Zebrafish)(Brachydanio rerio)
• Applications: ELISA, Western Blot
• Purity: Protein A/G
• Synonyms: STK3; Polyclonal Antibody; Rabbit anti-Danio rerio (Zebrafish)(Brachydanio rerio) STK3 Polyclonal Antibody; STK3 Antibody; Serine/threonine-protein kinase 3; EC 2.7.11.1; [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit; MST2/N; Serine/threonine-protein kinase 3 20kDa subunit; MST2/C)] stk3 zgc:55383; anti-STK3 antibody

• Host: Rabbit
• Reactivity: Danio rerio (Zebrafish)(Brachydanio rerio)
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Protein A/G
• Form/Format: Liquid; Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH7.4

• Applicable Applications for anti-STK3 antibody: ELISA (EIA), WB (Western Blot) (ensure identification of antigen)
• Immunogen: Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) stk3 protein
• Conjugation: Non-conjugate
• Modification: Unmodified
• Deliverables: 1. 200ug recombinant immunogen protein/peptide (positive control).; 2. 1mL preimmune serum (negative control); 3. 10mg rabbit polyclonal antibody purified by Protein A/G.
• Quality Guarantee: 1. Antibody purity >90% confirmed by SDS-PAGE.; 2. Antibody titer > 1: 64,000 confirmed by ELISA; 3. Western Blot positive for the immunogen protein (Not applicable for synthetic peptide).
• Complementary Antibody: Customer can choose 1 FREE antibody from the list below. Please specify the catalog # when order:; * 6*His Monoclonal Antibody #MBS1491670; * DYKDDDDK tag Monoclonal Antibody #MBS1493946; * GAPDH Monoclonal Antibody #MBS1495524; * GFP Monoclonal Antibody #MBS1496050; * Myc tag Monoclonal Antibody #MBS1497694; * GST Monoclonal Antibody #MBS1497871; * Sumo tag Monoclonal Antibody #MBS1498878; * Goat Anti-Rabbit IgG (H+L) Antibody; HRP conjugated #MBS7053510; * HA-Tag Monoclonal Antibody #MBS7135631; * E-Tag Monoclonal Antibody #MBS7135632; * TUBA1A Monoclonal Antibody #MBS7135645; * TUBB Monoclonal Antibody #MBS9018332
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

NCBI and Uniprot Product Information

• NCBI GI #: 41054445
• NCBI GeneID: 324125
• NCBI Accession #: NP_955966.1
• NCBI GenBank Nucleotide #: NM_199672.1
• UniProt Accession #: Q7ZUQ3
• Molecular Weight: 56,081 Da
• NCBI Official Full Name: serine/threonine-protein kinase 3
• NCBI Official Synonym Full Names: serine/threonine kinase 3 (STE20 homolog, yeast)
• NCBI Official Symbol: stk3
• NCBI Official Synonym Symbols: zgc:55383; wu:fc19e11
• NCBI Protein Information: serine/threonine-protein kinase 3
• UniProt Protein Name: Serine/threonine-protein kinase 3
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: stk3
• UniProt Synonym Gene Names: MST2/N; MST2/C

Uniprot Description

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.