Rabbit anti-Human, Mouse MMP11 Polyclonal Antibody | anti-MMP11 antibody
MMP11 Antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using MBS7127515(MMP11 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200))
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human renal cancer tissue using MBS7127515(MMP11 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200))
NCBI and Uniprot Product Information
NCBI Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
Uniprot Description
MMP11: May play an important role in the progression of epithelial malignancies. Belongs to the peptidase M10A family.
Protein type: Extracellular matrix; EC 3.4.24.-; Secreted, signal peptide; Protease; Secreted
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: proteinaceous extracellular matrix; Golgi lumen; extracellular region
Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding
Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; multicellular organismal development; proteolysis; negative regulation of fat cell differentiation