LY294002 2-(4-Morpholinyl)-8-phenyl-4H-1- benzopyran-4-one, Inhibitor
LY294002 2-(4-Morpholinyl)-8-phenyl-4H-1- benzopyran-4-one
Purity
Highly Purified~99% (TLC)
Synonyms
LY294002 2-(4-Morpholinyl)-8-phenyl-4H-1- benzopyran-4-one; inhibitor
Purity/Purification
Highly Purified
~99% (TLC)
~99% (TLC)
Form/Format
Supplied as a off-white to pale-yellow lyophilized powder. Reconstitute with sterile dH2O to 0.1-1mg/ml.
Biological Activity
IC50=1.4uM
Molecular Formula
C19H17NO3
Solubility
DMSO (~25mg/ml), warm ethanol (~25mg/ml)
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for LY294002 2-(4-Morpholinyl)-8-phenyl-4H-1- benzopyran-4-one, inhibitor
LY294002 is a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI3-kinase). LY294002 at a concentration of 50uM completely abolishes the PI3-K activity of intact neutrophils stimulated with fMet-Leu-Phe, without apparent cell toxicity. While concentration of 50uM is observed to be efficacious for inhibiting PI3-K activity in stimulated neutrophils, this concentration produces no significant inhibition of other kinases including PKC, PKA, MAP kinase, S6 kinase, EGF receptor tyrosine kinase, Src, PI4-kinase, diacylglycerol kinase, or rabbit kidney ATPase. This compound is a useful tool for identifying cellular event that are regulated by the PI3-kinase/Akt axis and is observed to induce apoptosis in many cell types by blocking the PI3-kinase/Akt anti-apoptotic pathway.
Product Categories/Family for LY294002 2-(4-Morpholinyl)-8-phenyl-4H-1- benzopyran-4-one, inhibitor
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Product Notes
The LY294002 2-(4-Morpholinyl)-8-phenyl-4H-1- benzopyran-4-one (Catalog #AAA655444) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LY294002 2-(4-Morpholinyl)-8-phenyl-4H-1- benzopyran-4-one, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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