Product Categories/Family for anti-TP53INP1 antibody
References
1. Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010). 2. Yeung, M.L., et al. Cancer Res. 68(21):8976-8985(2008). 3. Daniele, B. J. Clin. Gastroenterol. 42(4):336-337(2008). 4. Sawaya, M., et al. J. Clin. Gastroenterol. 42(4):351-355(2008). 5. Bernardo, M.V., et al. Biochem. Biophys. Res. Commun. 359(2):317-322(2007).
Uniprot Description
TP53INP1: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Tumor suppressor; Cell cycle regulation
Chromosomal Location of Human Ortholog: 8q22
Cellular Component: PML body; autophagic vacuole; cytoplasmic vesicle; nucleus; cytosol
Molecular Function: antioxidant activity; protein binding
Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; response to heat; apoptosis; positive regulation of transcription, DNA-dependent; autophagic cell death; response to stress; cell cycle arrest; negative regulation of cell migration; positive regulation of autophagy; autophagic vacuole formation
Product Notes
The TP53INP1 tp53inp1 (Catalog #
AAA6357524) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TP53INP1, NT (TP53INP1, P53DINP1, SIP, Tumor protein p53-inducible nuclear protein 1, Stress-induced protein, p53-dependent damage-inducible nuclear protein 1) (MaxLight 650) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TP53INP1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB), FLISA. Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the TP53INP1 tp53inp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"TP53INP1, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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