Related Product Information for anti-NLRC4 antibody
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.
Product Categories/Family for anti-NLRC4 antibody
References
Miao, E.A., et al. J. Clin. Immunol. 30(4):502-506(2010). Vinzing, M., et al. J. Immunol. 180(10):6808-6815(2008). Macaluso, F., et al. Exp. Dermatol. 16(8):692-698(2007). Bruey, J.M., et al. Cell 129(1):45-56(2007). Thalappilly, S., et al. FEBS J. 273(12):2766-2778(2006).
NCBI Description
This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Description
NLRC4: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 2p22.3
Cellular Component: spindle microtubule; cytoplasm; intracellular; nucleus; cytosol
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; ubiquitin-protein ligase activity; magnesium ion binding; cysteine protease inhibitor activity; ATP binding
Biological Process: caspase activation; detection of bacterium; positive regulation of apoptosis; regulation of signal transduction; protein ubiquitination; activation of NF-kappaB transcription factor; regulation of neuron apoptosis; defense response to bacterium; innate immune response; interleukin-1 beta secretion; inflammatory response; activation of innate immune response; protein homooligomerization; negative regulation of apoptosis
Disease: Autoinflammation With Infantile Enterocolitis; Familial Cold Autoinflammatory Syndrome 4
Product Notes
The NLRC4 nlrc4 (Catalog #
AAA6325743) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NLRC4, NT (NLRC4, CARD12, CLAN, CLAN1, IPAF, NLR family CARD domain-containing protein 4, CARD, LRR, and NACHT-containing protein, Caspase recruitment domain-containing protein 12, Ice protease-activating factor) (Biotin) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NLRC4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:100-500 ELISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the NLRC4 nlrc4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"NLRC4, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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