Mouse SHANK1 Monoclonal Antibody | anti-SHANK1 antibody
SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1, SPANK-1, SSTRIP, synamon) (APC)
NCBI and Uniprot Product Information
Uniprot Description
SHANK1: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Belongs to the SHANK family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: postsynaptic membrane; neuron projection; membrane; cytoplasm; dendrite; plasma membrane; dendritic spine; excitatory synapse; ionotropic glutamate receptor complex; intracellular; cell junction; N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function: protein C-terminus binding; somatostatin receptor binding; identical protein binding; ionotropic glutamate receptor binding; protein binding; protein complex binding; GKAP/Homer scaffold activity; SH3 domain binding
Biological Process: habituation; negative regulation of actin filament bundle formation; synapse maturation; determination of affect; olfactory behavior; long-term memory; righting reflex; cytoskeletal anchoring; adult behavior; protein complex assembly; social behavior; neuromuscular process controlling balance; associative learning