Mouse anti-Human Insulin Receptor R Monoclonal Antibody | anti-IRR antibody

Insulin Receptor R (Insulin Receptor-related Protein, Insulin Receptor-related Receptor, IR-related Receptor, INSRR, IRR) (PE)

Cat. Num. AAA6156259

• Gene Names: INSRR; IRR
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Purified
• Synonyms: Insulin Receptor R; Monoclonal Antibody; Insulin Receptor R (Insulin Receptor-related Protein; Insulin Receptor-related Receptor; IR-related Receptor; INSRR; IRR) (PE); anti-IRR antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 6E6
• Specificity: Recognizes human INSRR.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
• Sequence Length: 1297

• Applicable Applications for anti-IRR antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: INSRR (NP_055030, 651-760aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
• Conjugate: PE
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-IRR antibody

The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor composed of two alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Member of the insulin RTK family, IRR shares high homology with the insulin (IR) and the insulin-like growth factor-1 receptor (IGF-1R), but doesn't bind any of IR and IGF-1R known ligands. In contrast to the widespread patterns of expression to IR and IGF-1R, IRR demonstrates a very restricted cellular distribution in a subset of tissues of neuronal origin and its biological functions are still unknown.

Product Categories/Family for anti-IRR antibody

Antibodies; Receptors; Tyrosine Kinase

NCBI and Uniprot Product Information

• NCBI GI #: 31657140
• NCBI GeneID: 3645
• NCBI Accession #: NP_055030
• NCBI GenBank Nucleotide #: NP_055030.1
• UniProt Accession #: P14616
• NCBI Official Full Name: insulin receptor-related protein
• NCBI Official Synonym Full Names: insulin receptor related receptor
• NCBI Official Symbol: INSRR
• NCBI Official Synonym Symbols: IRR
• NCBI Protein Information: insulin receptor-related protein
• UniProt Protein Name: Insulin receptor-related protein
• UniProt Gene Name: INSRR
• UniProt Synonym Gene Names: IRR; IRR
• UniProt Entry Name: INSRR_HUMAN

Uniprot Description

IRR: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Protein type: Protein kinase, TK; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; InsR family

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: integral to plasma membrane; receptor complex

Molecular Function: insulin receptor substrate binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; male sex determination; actin cytoskeleton reorganization; transmembrane receptor protein tyrosine kinase signaling pathway