Adenanthin, Inhibitor
Adenanthin
Purity
98.00%
Synonyms
Adenanthin; AdenanthinA; Adenanthin-A; Adenanthin A; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: Soluble
(<1mg/ refers to the product slightly soluble or insoluble)
(<1mg/ refers to the product slightly soluble or insoluble)
Formula
C26H34O9
SMILES
O=C([C@]([C@H]1OC(C)=O)(C2)[C@]3([H])[C@]4(C)[C@@H](OC(C)=O)C[C@H](O)C(C)(C)[C@@]4([H])C1=O)C([C@]2([H])C[C@@H]3OC(C)=O)=C
CAS Number
111917-59-0
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Adenanthin, inhibitor
Adenanthin, a natural inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells.
References
Siernicka M, Winiarska M, Bajor M, Firczuk M, Muchowicz A, Bobrowicz M, Fauriat C, Golab J, Olive D, Zagozdzon R. Adenanthin, a new inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells. Immunology. 2015 Sep;146(1):173-83. doi: 10.1111/imm.12494. Epub 2015 Jul 8. PubMed PMID: 26094816; PubMed Central PMCID: PMC4552512.
Soethoudt M, Peskin AV, Dickerhof N, Paton LN, Pace PE, Winterbourn CC. Interaction of adenanthin with glutathione and thiol enzymes: selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling. Free Radic Biol Med. 2014 Dec;77:331-9. doi: 10.1016/j.freeradbiomed.2014.09.025. Epub 2014 Oct 5. PubMed PMID: 25289458.
Hou JK, Huang Y, He W, Yan ZW, Fan L, Liu MH, Xiao WL, Sun HD, Chen GQ. Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells. Cell Death Dis. 2014 Sep 4;5:e1400. doi: 10.1038/cddis.2014.345. PubMed PMID: 25188510; PubMed Central PMCID: PMC4540188.
Muchowicz A, Firczuk M, Chlebowska J, Nowis D, Stachura J, Barankiewicz J, Trzeciecka A, Klossowski S, Ostaszewski R, Zagozdzon R, Pu JX, Sun HD, Golab J. Adenanthin targets proteins involved in the regulation of disulphide bonds. Biochem Pharmacol. 2014 May 15;89(2):210-6. doi: 10.1016/j. Bcp.2014.02.022. Epub 2014 Mar 11. PubMed PMID: 24630929.
Soethoudt M, Peskin AV, Dickerhof N, Paton LN, Pace PE, Winterbourn CC. Interaction of adenanthin with glutathione and thiol enzymes: selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling. Free Radic Biol Med. 2014 Dec;77:331-9. doi: 10.1016/j.freeradbiomed.2014.09.025. Epub 2014 Oct 5. PubMed PMID: 25289458.
Hou JK, Huang Y, He W, Yan ZW, Fan L, Liu MH, Xiao WL, Sun HD, Chen GQ. Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells. Cell Death Dis. 2014 Sep 4;5:e1400. doi: 10.1038/cddis.2014.345. PubMed PMID: 25188510; PubMed Central PMCID: PMC4540188.
Muchowicz A, Firczuk M, Chlebowska J, Nowis D, Stachura J, Barankiewicz J, Trzeciecka A, Klossowski S, Ostaszewski R, Zagozdzon R, Pu JX, Sun HD, Golab J. Adenanthin targets proteins involved in the regulation of disulphide bonds. Biochem Pharmacol. 2014 May 15;89(2):210-6. doi: 10.1016/j. Bcp.2014.02.022. Epub 2014 Mar 11. PubMed PMID: 24630929.
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Product Notes
The Adenanthin (Catalog #AAA5756619) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Adenanthin, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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