Desmin Native Protein | DES native protein

Desmin protein (Chicken)

Cat. Num. AAA537523

• Gene Names: DES; CSM1; CSM2; LGMD2R
• Applications: User optimized
• Purity: > 98%, (determined by SDS gel electrophoresis)
• Synonyms: Desmin; Desmin protein (Chicken); DES native protein

• Host: Chicken gizzard
• Purity/Purification: > 98%, (determined by SDS gel electrophoresis)
• Form/Format: Lyophilized powder. Reconstitute with 200ul of distilled water. Final solution is 10mM sodium phosphate buffer, pH 7.5, 6M urea, 2mM DTT, 1mM EDTA, and 10mM methylammonium chloride.
• Concentration: 250ug, lyophilized. After reconstitution concentration is 1 mg/ml. (varies by lot)
• Sequence Length: 470

• Applicable Applications for DES native protein: User optimized
• Application Notes: Protein standard in 1D and 2D SDS gel electrophoresis, Immunoassays, and immunization.
• Species: Chicken
• Protein Type: Native
• Isoelectric Point: pI 5.4
• Biohazard: Use normal laboratory precautions when handling this material.
• Preparation and Storage: Ships ambient or refrigerated. Upon receipt, store at 4°C. Aliquot and store at -20°C after reconstitution.

Related Product Information for DES native protein

Desmin is the main intermediate filament in mature skeletal, cardiac and smooth-muscle cells. The antibody can be used to distinguish rhabdomyosarcomas and leiomyosarcomas from other soft tissue tumors, lymphomas and carcinomas. Mab D9 does not crossreact with other intermediate filament proteins and is useful for the identification of myodifferentiation (also in tumors).

Product Categories/Family for DES native protein

Cell Biology; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 55749932
• NCBI GeneID: 1674
• NCBI Accession #: NP_001918.3
• NCBI GenBank Nucleotide #: NM_001927.3
• UniProt Accession #: P17661; Q15787; Q549R7; Q549R8; Q549R9; Q8IZR1; Q8IZR6; Q8NES2; Q8NEU6; Q8TAC4; Q8TCX2; Q8TD99
• NCBI Official Full Name: desmin
• NCBI Official Synonym Full Names: desmin
• NCBI Official Symbol: DES
• NCBI Official Synonym Symbols: CSM1; CSM2; LGMD2R
• NCBI Protein Information: desmin
• UniProt Protein Name: Desmin
• Protein Family: Desmin
• UniProt Gene Name: DES
• UniProt Entry Name: DESM_HUMAN

NCBI Description

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]

Uniprot Description

desmin: a class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: intermediate filament; fascia adherens; Z disc; neuromuscular junction; cytosol; sarcolemma

Molecular Function: identical protein binding; protein binding; structural constituent of cytoskeleton; cytoskeletal protein binding

Biological Process: muscle contraction; cytoskeleton organization and biogenesis; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Dilated, 1i; Scapuloperoneal Syndrome, Neurogenic, Kaeser Type; Myopathy, Myofibrillar, 1; Muscular Dystrophy, Limb-girdle, Type 2r