Human Protein ZNF750 ELISA Kit | ZNF750 elisa kit
Human Protein ZNF750 (ZNF750) ELISA Kit
Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate ZNF750 in Human serum, plasma, tissue homogenates. An antibody specific for ZNF750 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any ZNF750 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ZNF750 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ZNF750 bound in the initial step. The color development is stopped and the intensity of the color is measured.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Mutations in this gene have been associated with seborrhea-like dermatitis with psoriasiform elements. [provided by RefSeq, Jul 2008]
Uniprot Description
ZNF750: Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression. Defects in ZNF750 are the cause of Seborrhea-like dermatitis with psoriasiform (SLDP). SLDP is characterized by a chronic fine diffuse scaly erythematous rash on the face, particularly on the chin, nasolabial folds and eyebrows, around earlobes and over the scalp. The rash exacerbate in the winter, with emotional stress and after strenuous physical activity. Hyperkeratosis of skin over the elbows, knees, palms, soles and metacarpophalangeal joints is evident. There is no arthralgia, arthritis or neurological disorders.
Protein type: C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus
Molecular Function: metal ion binding; protein binding
Biological Process: cell differentiation; epidermis development; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Disease: Seborrhea-like Dermatitis With Psoriasiform Elements
Research Articles on ZNF750
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Product Notes
The Human ZNF750 znf750 (Catalog #AAA282365) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA282365 ELISA Kit recognizes Human ZNF750. It is sometimes possible for the material contained within the vial of "Protein ZNF750, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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