Rabbit anti-Human PRUNE Polyclonal Antibody | anti-PRUNE antibody
PRUNE Polyclonal Antibody
ELISA: 1:5000-1:10000
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using PRUNE Polyclonal Antibody at dilution of 1:40(×200))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Description
PRUNE: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. Belongs to the PPase class C family. Prune subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Nucleotide Metabolism - purine; EC 3.6.1.1
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: focal adhesion; cytoplasm; nucleus
Molecular Function: protein binding; inorganic diphosphatase activity; metal ion binding
Biological Process: metabolic process