Rabbit anti-Mouse, Rat NEDD8 Polyclonal Antibody | anti-NEDD8 antibody
NEDD8 Polyclonal Antibody
NCBI and Uniprot Product Information
Uniprot Description
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.