SCO1 Homolog Mitochondrial SCO1/SCOD1 Recombinant Protein | SCOD1 recombinant protein

Recombinant Human Protein SCO1 Homolog Mitochondrial SCO1/SCOD1 Protein (N-GST)

Cat. Num. AAA2553158

• Gene Names: SCO1; SCOD1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: SCO1 Homolog Mitochondrial SCO1/SCOD1; Recombinant Human Protein SCO1 Homolog Mitochondrial SCO1/SCOD1 Protein (N-GST); Protein SCO1 Homolog Mitochondrial; SCO1; SCOD1; SCOD1 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 50mM PB, 1mM DTT, pH 7.2.
• Sequence Positions: Gly132-Ser300
• Sequence Length: 301

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N-GST
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for SCOD1 recombinant protein

Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by high rates of Oxidative Phosphorylation (OxPhos). SCO1 is thought to play a important role in cellular copper homeostasis, mitochondrial redox signaling and insertion of copper into the active site of COX. The defects of SCO1 can result in Mitochondrial Complex IV Deficiency (MT-C4D). A disorder of the mitochondrial respiratory chain has heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs.

NCBI and Uniprot Product Information

• NCBI GI #: 4759068
• NCBI GeneID: 6341
• NCBI Accession #: NP_004580.1
• NCBI GenBank Nucleotide #: NM_004589.3
• UniProt Accession #: O75880; B2RDM0
• Molecular Weight: Molecular Mass: 20.1 kDa; Actual Protein Molecular Mass: 19 kDa
• NCBI Official Full Name: protein SCO1 homolog, mitochondrial
• NCBI Official Synonym Full Names: SCO1, cytochrome c oxidase assembly protein
• NCBI Official Symbol: SCO1
• NCBI Official Synonym Symbols: SCOD1
• NCBI Protein Information: protein SCO1 homolog, mitochondrial
• UniProt Protein Name: Protein SCO1 homolog, mitochondrial
• UniProt Gene Name: SCO1
• UniProt Synonym Gene Names: SCOD1

NCBI Description

Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478, PubMed:15229189). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 ().