Msx2-interacting protein (Spen) Recombinant Protein | Spen recombinant protein

Recombinant Mouse Msx2-interacting protein (Spen) , partial

• Gene Names: Spen; Mint; mKIAA0929
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Msx2-interacting protein (Spen); Recombinant Mouse Msx2-interacting protein (Spen); partial; Spen recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 3,553

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Spen recombinant protein

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.

NCBI and Uniprot Product Information

• NCBI GI #: 120587001
• NCBI GeneID: 56381
• NCBI Accession #: NP_062737.2
• NCBI GenBank Nucleotide #: NM_019763.2
• UniProt Accession #: Q62504; Q80TN9; Q99PS4; Q9QZW2
• Molecular Weight: 389,153 Da
• NCBI Official Full Name: msx2-interacting protein isoform 1
• NCBI Official Synonym Full Names: spen family transcription repressor
• NCBI Official Symbol: Spen
• NCBI Official Synonym Symbols: Mint; mKIAA0929
• NCBI Protein Information: msx2-interacting protein
• UniProt Protein Name: Msx2-interacting protein
• Protein Family: Msx2-interacting protein
• UniProt Gene Name: Spen
• UniProt Synonym Gene Names: Kiaa0929; Mint; Sharp

Uniprot Description

May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways, such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.