Tubulin Polymerization Promoting Protein Recombinant Protein | TPPP recombinant protein
Recombinant Human Tubulin Polymerization Promoting Protein
Gene Names
TPPP; p24; p25; TPPP1; TPPP/p25; p25alpha
Purity
Purity as determined by densitometric image analysis is greater than 85%.
Synonyms
Tubulin Polymerization Promoting Protein; Recombinant Human Tubulin Polymerization Promoting Protein; TPPP Human; Tubulin Polymerization Promoting Protein Human Recombinant; Tubulin polymerization-promoting protein; TPPP; 25 kDa brain-specific protein; TPPP/p25; p24; p25-alpha; TPPP1; p25; p25alpha; TPPP recombinant protein
Host
E Coli
Purity/Purification
Purity as determined by densitometric image analysis is greater than 85%.
Form/Format
TPPP filtered (0.4 um) and lyophilized from 0.5mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 7.4.
Filtered White lyophilized (freeze-dried) powder.
Filtered White lyophilized (freeze-dried) powder.
Sequence
MKHHHHHHASMADKAKPAKA ANRTPPKSPG DPSKDRAAKR LSLESEGAGE GAAASPELSA LEEAFRRFAV HGDARATGRE MHGKNWSKLC KDCQVIDGRN VTVTDVDIVF SKIKGKSCRT ITFEQFQEAL EELAKKRFKD KSSEEAVREV HRLIEGKAPI ISGVTKAISS PTVSRLTDTT KFTGSHKERF DPSGKGKGKA GRVDLVDESG YVSGYKHAGT YDQKVQGGK.
Sequence Length
219
Solubility
It is recommended to add 200 ul deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. TPPP is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Preparation and Storage
Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
Related Product Information for TPPP recombinant protein
Description: TPPP Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 229 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 24.9kDa (calculated).
Introduction: Tubulin Polymerization Promoting Protein (TPPP) probably plays a part in the polymerization of tubulin into microtubules, as well as in microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. TPPP may also have a role in mitotic spindle assembly and nuclear envelope breakdown. TPPP/p235 level in cerebrospinal fluid is considerably higher in multiple sclerosis patients.
Introduction: Tubulin Polymerization Promoting Protein (TPPP) probably plays a part in the polymerization of tubulin into microtubules, as well as in microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. TPPP may also have a role in mitotic spindle assembly and nuclear envelope breakdown. TPPP/p235 level in cerebrospinal fluid is considerably higher in multiple sclerosis patients.
Product Categories/Family for TPPP recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
23,694 Da
NCBI Official Full Name
tubulin polymerization-promoting protein
NCBI Official Synonym Full Names
tubulin polymerization promoting protein
NCBI Official Symbol
TPPP
NCBI Official Synonym Symbols
p24; p25; TPPP1; TPPP/p25; p25alpha
NCBI Protein Information
tubulin polymerization-promoting protein; 25 kDa brain-specific protein; brain specific protein p25 alpha; glycogen synthase kinase 3 (GSK3) inhibitor p24; p25-alpha
UniProt Protein Name
Tubulin polymerization-promoting protein
Protein Family
UniProt Gene Name
TPPP
UniProt Synonym Gene Names
TPPP1; TPPP
UniProt Entry Name
TPPP_HUMAN
Uniprot Description
TPPP: May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. Belongs to the TPPP family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 5p15.3
Cellular Component: microtubule; perinuclear region of cytoplasm; cytoplasm; nucleus
Molecular Function: tubulin binding; protein binding; microtubule binding
Biological Process: positive regulation of protein polymerization; positive regulation of protein complex assembly; microtubule bundle formation; microtubule polymerization
Research Articles on TPPP
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Product Notes
The TPPP tppp (Catalog #AAA145953) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MKHHHHH HASMAD KAKPAKA ANRTPPKSPG DPSKDRAAKR LSLESEGAGE GAAASPELSA LEEAFRRFAV HGDARATGRE MHGKNWSKLC KDCQVIDGRN VTVTDVDIVF SKIKGKSCRT ITFEQFQEAL EELAKKRFKD KSSEEAVREV HRLIEGKAPI ISGVTKAISS PTVSRLTDTT KFTGSHKERF DPSGKGKGKA GRVDLVDESG YVSGYKHAGT YDQKVQGGK. . It is sometimes possible for the material contained within the vial of "Tubulin Polymerization Promoting Protein, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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