Suppressor of cytokine signaling 1 (Socs1) Recombinant Protein | Socs1 recombinant protein

Recombinant Rat Suppressor of cytokine signaling 1 (Socs1)

Cat. Num. AAA1353968

• Gene Names: Socs1; Cish1; Socs-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Suppressor of cytokine signaling 1 (Socs1); Recombinant Rat Suppressor of cytokine signaling 1 (Socs1); Socs1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-212, full length protein
• Sequence: MVARNQVAADNAISPASEPRRRPEPSSSSSSSSPAAPRRPRPCPVVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI
• Sequence Length: 212

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Socs1 recombinant protein

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2
GM-CSF, and interferon (IFN)-gamma. This protein functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

NCBI and Uniprot Product Information

• NCBI GI #: 20178091
• NCBI GeneID: 252971
• UniProt Accession #: Q9QX78
• Molecular Weight: 23,826 Da
• NCBI Official Full Name: Suppressor of cytokine signaling 1
• NCBI Official Synonym Full Names: suppressor of cytokine signaling 1
• NCBI Official Symbol: Socs1
• NCBI Official Synonym Symbols: Cish1; Socs-1
• NCBI Protein Information: suppressor of cytokine signaling 1
• UniProt Protein Name: Suppressor of cytokine signaling 1
• Protein Family: Suppressor of cytokine signaling
• UniProt Gene Name: Socs1
• UniProt Synonym Gene Names: SOCS-1

NCBI Description

suppressor of cytokine signalling [RGD, Feb 2006]

Uniprot Description

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (). SOCS1 appears to be a negative regulator in IGF1R signaling pathway (). Interacts with TRIM8 ().