PIK3CB cdna clone
PIK3CB cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Uniprot Description
PIK3CB: catalytic subunit of phosphoinositide-3-kinase beta. Catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration and cell survival. PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. Expressed ubiquitously.
Protein type: Kinase, lipid; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153
Chromosomal Location of Human Ortholog: 3q22.3
Cellular Component: cytosol; intercellular bridge; nucleolus; nucleus; phosphoinositide 3-kinase complex; plasma membrane
Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; phosphoinositide 3-kinase activity; protein binding
Biological Process: activation of MAPK activity; cell migration; chemotaxis; G-protein coupled receptor protein signaling pathway; leukocyte migration; phosphatidylinositol biosynthetic process; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; platelet activation; positive regulation of autophagy; regulation of cell-matrix adhesion; regulation of phosphoinositide 3-kinase cascade; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway
Research Articles on PIK3CB
Similar Products
Product Notes
The PIK3CB pik3cb (Catalog #AAA1271318) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTGCTTCA GTTTCATAAT GCCTCCTGCT ATGGCAGACA TCCTTGACAT CTGGGCGGTG GATTCACAGA TAGCATCTGA TGGCTCCATA CCTGTGGATT TCCTTTTGCC CACTGGGATT TATATCCAGT TGGAGGTACC TCGGGAAGCT ACCATTTCTT ATATTAAGCA GATGTTATGG AAGCAAGTTC ACAATTACCC AATGTTCAAC CTCCTTATGG ATATTGACTC CTATATGTTT GCATGTGTGA ATCAGACTGC TGTATATGAG GAGCTTGAAG ATGAAACACG AAGACTCTGT GATGTCAGAC CTTTTCTTCC AGTTCTCAAA TTAGTGACAA GAAGTTGTGA CCCAGGGGAA AAATTAGACT CAAAAATTGG AGTCCTTATA GGAAAAGGTC TGCATGAATT TGATTCCTTG AAGGATCCTG AAGTAAATGA ATTTCGAAGA AAAATGCGCA AATTCAGCGA GGAAAAAATC CTGTCACTTG TGGGATTGTC TTGGATGGAC TGGCTAAAAC AAACATATCC ACCAGAGCAT GAACCATCCA TCCCTGAAAA CTTAGAAGAT AAACTTTATG GGGGAAAGCT CATCGTAGCT GTTCATTTTG AAAACTGCCA GGACGTGTTT AGCTTTCAAG TGTCTCCTAA TATGAATCCT ATCAAAGTAA ATGAATTGGC AATCCAAAAA CGTTTGACTA TTCATGGGAA GGAAGATGAA GTTAGCCCCT ATGATTATGT GTTGCAAGTC AGCGGGAGAG TAGAATATGT TTTTGGTGAT CATCCACTAA TTCAGTTCCA GTATATCCGG AACTGTGTGA TGAACAGAGC CCTGCCCCAT TTTATACTTG TGGAATGCTG CAAGATCAAG AAAATGTATG AACAAGAAAT GATTGCCATA GAGGCTGCCA TAAATCGAAA TTCATCTAAT CTTCCTCTTC CATTACCACC AAAGAAAACA CGAATTATTT CTCATGTTTG GGAAAATAAC AACCCTTTCC AAATTGTCTT GGTTAAGGGA AATAAACTTA ACACAGAGGA AACTGTAAAA GTTCATGTCA GGGCTGGTCT TTTTCATGGT ACTGAGCTCC TGTGTAAAAC CATCGTAAGC TCAGAGGTAT CAGGGAAAAA TGATCATATT TGGAATGAAC CACTGGAATT TGATATTAAT ATTTGTGACT TACCAAGAAT GGCTCGATTA TGTTTTGCTG TTTATGCAGT TTTGGATAAA GTAAAAACGA AGAAATCAAC GAAAACTATT AATCCCTCTA AATATCAGAC CATCAGGAAA GCTGGAAAAG TGCATTATCC TGTAGCGTGG GTAAATACGA TGGTTTTTGA CTTTAAAGGA CAATTGAGAA CTGGAGACAT AATATTACAC AGCTGGTCTT CATTTCCTGA TGAACTCGAA GAAATGTTGA ATCCAATGGG AACTGTTCAA ACAAATCCAT ATACTGAAAA TGCAACAGCT TTGCATGTTA AATTTCCAGA GAATAAAAAA CAACCTTATT ATTACCCTCC CTTCGATAAG ATTATTGAAA AGGCAGCTGA GATTGCAAGC AGTGATAGTG CTAATGTGTC AAGTCGAGGT GGAAAAAAGT TTCTTCCTGT ATTGAAAGAA ATCTTGGACA GGGATCCCTT GTCTCAACTG TGTGAAAATG AAATGGATCT TATTTGGACT TTGCGACAAG ACTGCCGAGA GATTTTCCCA CAATCACTGC CAAAATTACT GCTGTCAATC AAGTGGAATA AACTTGAGGA TGTTGCTCAG CTTCAGGCGC TGCTTCAGAT TTGGCCTAAA CTGCCCCCCC GGGAGGCCCT AGAGCTTCTG GATTTCAACT ATCCAGACCA GTACGTTCGA GAATATGCTG TAGGCTGCCT GCGACAGATG AGTGATGAAG AACTTTCTCA ATATCTTTTA CAACTGGTGC AAGTGTTAAA ATATGAGCCT TTTCTTGATT GTGCCCTCTC TAGATTCCTA TTAGAAAGAG CACTTGGTAA TCGGAGGATA GGGCAGTTTC TATTTTGGCA TCTTAGGTCA GAAGTGCACA TTCCTGCTGT CTCAGTACAA TTTGGTGTCA TCCTTGAAGC ATACTGCCGG GGAAGTGTGG GGCACATGAA AGTGCTTTCT AAGCAGGTTG AAGCACTCAA TAAGTTAAAA ACTTTAAATA GTTTAATCAA ACTGAATGCC GTGAAGTTAA ACAGAGCCAA AGGGAAGGAG GCCATGCATA CCTGTTTAAA ACAGAGTGCT TACCGGGAAG CCCTCTCTGA CCTGCAGTCA CCCCTGAACC CATGTGTTAT CCTCTCAGAA CTCTATGTTG AAAAGTGCAA ATACATGGAT TCCAAAATGA AGCCTTTGTG GCTGGTATAC AATAACAAGG TATTTGGTGA GGATTCAGTT GGAGTGATTT TTAAAAATGG TGATGATTTA CGACAGGATA TGTTGACACT CCAAATGTTG CGCTTGATGG ATTTACTCTG GAAAGAAGCT GGTTTGGATC TTCGGATGTT GCCTTATGGC TGTTTAGCAA CAGGAGATCG CTCTGGCCTC ATTGAAGTTG TGAGCACCTC TGAAACAATT GCTGACATTC AGCTGAACAG TAGCAATGTG GCTGCTGCAG CAGCCTTCAA CAAAGATGCC CTTCTGAACT GGCTTAAAGA ATACAACTCT GGGGATGACC TGGACCGAGC CATTGAGGAA TTTACACTGT CCTGTGCTGG CTACTGTGTA GCTTCTTATG TCCTTGGGAT TGGTGACAGA CATAGTGACA ACATCATGGT CAAAAAAACT GGCCAGCTCT TCCACATTGA CTTTGGACAT ATTCTTGGAA ATTTCAAATC TAAGTTTGGC ATTAAAAGGG AGCGAGTGCC TTTTATTCTT ACCTATGATT TCATCCATGT CATTCAACAA GGAAAAACAG GAAATACAGA AAAGTTTGGC CGGTTCCGCC AGTGTTGTGA GGATGCATAT CTGATTTTAC GACGGCATGG GAATCTCTTC ATCACTCTCT TTGCGCTGAT GTTGACTGCA GGGCTTCCTG AACTCACATC AGTCAAAGAT ATACAGTATC TTAAGGACTC TCTTGCATTA GGGAAGAGTG AAGAAGAAGC ACTCAAACAG TTTAAGCAAA AATTTGATGA GGCGCTCAGG GAAAGCTGGA CTACTAAAGT GAACTGGATG GCCCACACAG TTCGGAAAGA CTACAGATCT TAA. It is sometimes possible for the material contained within the vial of "PIK3CB, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
