TAF1B cdna clone
TAF1B cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Description
TAF1B: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. Belongs to the RRN7/TAF1B family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription initiation complex; Nucleolus
Chromosomal Location of Human Ortholog: 2p25
Cellular Component: nucleoplasm
Molecular Function: protein binding; TATA-binding protein binding
Biological Process: positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter
Research Articles on TAF1B
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Product Notes
The TAF1B taf1b (Catalog #AAA1269359) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggacctcg aggagtcgga agagtttaaa gaacgctgta ctcagtgtgc tgctgtctca tggggtctta ctgatgaagg caaatattat tgcacttctt gccacaatgt tacagagaga tatcaggaag ttacaaacac tgatcttatt cctaataccc aaataaaagc cctcaaccgg gggcttaaaa aaaaaaacaa tactgaaaaa ggctgggatt ggtatgtgtg tgaaggtttc cagtatattc tttatcaaca agcagaagcc ttaaagaacc ttggagtagg cccagagtta aagaacgatg ttttacataa tttttggaag cgctaccttc agaagagcaa gcaggcatat tgtaagaacc cagtttatac cactggaagg aaacctacgg tattagaaga taatctaagt cattcagact gggctagtga gcctgagctg ctaagtgatg tcagctgtcc tccttttctt gaaagtggag cggagtctca gtctgacatc cacactcgaa aacctttccc cgtcagcaaa gcatcacaat cagaaacgtc tgtctgctct ggatctctgg atggagttga atactcacaa cgaaaggaga agggaatcgt gaagatgacc atgccacaga cacttgcctt ctgttatctg tccttacttt ggcagagaga agcaataaca ctttcagatc ttttgaggtt tgttgaagag gaccatattc cttacataaa tgcttttcag cattttccag aacagatgaa attatatgga cgtgacagag gaatctttgg tatagagtct tggcctgact acgaggacat ctataaaaaa acaatagaag ttggaacatt tttagatttg cctcgttttc cagacataac tgaagactgc tatcttcatc ccaacatact gtgtatgaaa tacttgatgg aagtcaacct ccctgatgaa atgcatagct taacttgcca cgtggtaaaa atgactggaa tgggagaagt ggattttctg acatttgatc ctatagccaa aatggcaaaa gctgttaagt acgatgtaca agctgtagct atcattgtgg tggtattgaa actgctcttt ctattggatg acagtttcga gtggtctttg tctaatcttg ctgaaaagca taatgaaaag aacaaaaaag ataagccatg gtttgatttc agaaagtggt accaaattat gaagaaagct tttgatgaga aaaaacaaaa atgggaagaa gcaagggcca agtacctgtg gaaaagtgaa aagccactct actactcatt tgtcgacaaa ccagtagcat ataaaaaaag agaaatggtg gtgaatctac agaaacaatt tagcacactg gtcgattcaa cagcaactgc tggaaaaaaa agcccttcaa gttttcagtt caactggact gaagaggaca ctgatagaac gtgtttccat ggacacagcc ttcagggagt cctgaaagag aaaggccaat cactgctgac taagaattca ttatattggc ttagtacaca gaaattctgc agatgctatt gtacacatgt gacaacctat gaagaatcaa attattctct gagttatcag tttatactaa atctcttctc cttcctgctc agaataaaga cttcccttct ccatgaagaa gtgagcttag ttgagaagaa actttttgag aaaaaataca gtgtaaaaag aaagaaatca agatccaaga aagtgagacg acattga. It is sometimes possible for the material contained within the vial of "TAF1B, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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